| http://purl.uniprot.org/citations/18383040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18383040 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-10 is a potent anti-inflammatory molecule, which regulates TNF-alpha at multiple levels. We investigated whether IL-10 also modulated the activity of the TNF-alpha-converting enzyme (TACE). Using an ex vivo fluorogenic assay we observed that LPS rapidly induced TACE activity in monocytes coinciding with release of soluble TNF-alpha. In the presence of IL-10, TNF-alpha production and activation of surface TACE was significantly inhibited. Paradoxically, both LPS with or without IL-10 led to accumulation of surface TACE (albeit catalytically inactive) over a 24 h period. We investigated whether this was mediated through induction of endogenous tissue inhibitor metalloproteinase-3 (TIMP-3). We found that the inhibition of TACE activity at 2 h by IL-10 was not TIMP-3 dependent but that the late accumulation of surface TACE was prevented with TIMP-3 antibodies. Furthermore, induction of endogenous TIMP-3 was observed by western blotting in both LPS- and in LPS with IL-10-treated monocytes from 6 to 8 h of culture. These results indicate that IL-10 further regulates TNF-alpha by modulating TACE activation at early time points and by contributing to the induction of TIMP-3, the natural inhibitor of active TACE, at later time points. These observations add to our understanding of inflammation and the importance of homeostatic regulators of these events."xsd:string |
| http://purl.uniprot.org/citations/18383040 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200737821"xsd:string |
| http://purl.uniprot.org/citations/18383040 | http://purl.uniprot.org/core/author | "Green P."xsd:string |
| http://purl.uniprot.org/citations/18383040 | http://purl.uniprot.org/core/author | "Takata M."xsd:string |
| http://purl.uniprot.org/citations/18383040 | http://purl.uniprot.org/core/author | "Brennan F.M."xsd:string |
| http://purl.uniprot.org/citations/18383040 | http://purl.uniprot.org/core/author | "Robertshaw H.J."xsd:string |
| http://purl.uniprot.org/citations/18383040 | http://purl.uniprot.org/core/author | "Amjadi P."xsd:string |
| http://purl.uniprot.org/citations/18383040 | http://purl.uniprot.org/core/author | "Alvarez-Iglesias M."xsd:string |
| http://purl.uniprot.org/citations/18383040 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18383040 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/18383040 | http://purl.uniprot.org/core/pages | "1106-1117"xsd:string |
| http://purl.uniprot.org/citations/18383040 | http://purl.uniprot.org/core/title | "Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism."xsd:string |
| http://purl.uniprot.org/citations/18383040 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/18383040 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18383040 |
| http://purl.uniprot.org/citations/18383040 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18383040 |
| http://purl.uniprot.org/uniprot/P78536#attribution-3B339477D543567270EDB8902D6DEED0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18383040 |
| http://purl.uniprot.org/uniprot/P22301#attribution-3B339477D543567270EDB8902D6DEED0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18383040 |
| http://purl.uniprot.org/uniprot/P35625#attribution-FB7034E42A3B185809019B12D807C414 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18383040 |
| http://purl.uniprot.org/uniprot/#_B4DNZ4-mappedCitation-18383040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18383040 |
| http://purl.uniprot.org/uniprot/#_P35625-mappedCitation-18383040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18383040 |
| http://purl.uniprot.org/uniprot/#_Q6LEP5-mappedCitation-18383040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18383040 |
| http://purl.uniprot.org/uniprot/P35625 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18383040 |
| http://purl.uniprot.org/uniprot/B4DNZ4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18383040 |
| http://purl.uniprot.org/uniprot/Q6LEP5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/18383040 |