| http://purl.uniprot.org/citations/18402937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18402937 | http://www.w3.org/2000/01/rdf-schema#comment | "Vasopressin (VP) secreted within the brain modulates neuronal function acting as a neurotransmitter. Based on the observation that VP prevented serum deprivation-induced cell death in the neuronal cell line, H32, which expresses endogenous V1 receptors, we tested the hypothesis that VP has anti-apoptotic properties. Flow cytometry experiments showed that 10 nM VP prevented serum deprivation-induced cell death and annexin V binding. Serum deprivation increased caspase-3 activity in a time and serum concentration dependent manner, and VP prevented these effects through interaction with receptors of V1 subtype. The signaling pathways mediating the anti-apoptotic effect of VP involve mitogen activated protein (MAP) kinase and extracellular signal-regulated kinases (ERK), Ca(2+)/calmodulin dependent kinase (CaMK) and protein kinase C (PKC). Western blot analyses revealed time-dependent decreases of Bad phosphorylation and increases in cytosolic levels of cytochrome c following serum deprivation, effects which were prevented by 10 nM VP. These data demonstrate that activation of endogenous V1 VP receptors prevents serum deprivation-induced apoptosis, through phosphorylation-inactivation of the pro-apoptotic protein, Bad, and consequent decreases in cytosolic cytochrome c and caspase-3 activation. The data suggest that VP has anti-apoptotic activity in neurons and that VP may act as a neuroprotective agent in the brain."xsd:string |
| http://purl.uniprot.org/citations/18402937 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.expneurol.2008.02.023"xsd:string |
| http://purl.uniprot.org/citations/18402937 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/18402937 | http://purl.uniprot.org/core/author | "Aguilera G."xsd:string |
| http://purl.uniprot.org/citations/18402937 | http://purl.uniprot.org/core/author | "Volpi S."xsd:string |
| http://purl.uniprot.org/citations/18402937 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18402937 | http://purl.uniprot.org/core/name | "Exp Neurol"xsd:string |
| http://purl.uniprot.org/citations/18402937 | http://purl.uniprot.org/core/pages | "529-538"xsd:string |
| http://purl.uniprot.org/citations/18402937 | http://purl.uniprot.org/core/title | "Anti-apoptotic actions of vasopressin in H32 neurons involve MAP kinase transactivation and Bad phosphorylation."xsd:string |
| http://purl.uniprot.org/citations/18402937 | http://purl.uniprot.org/core/volume | "211"xsd:string |
| http://purl.uniprot.org/citations/18402937 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18402937 |
| http://purl.uniprot.org/citations/18402937 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18402937 |
| http://purl.uniprot.org/uniprot/Q92934#attribution-9A7605270E7FB586DD782642234E7B06 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18402937 |
| http://purl.uniprot.org/uniprot/P51812#attribution-9A7605270E7FB586DD782642234E7B06 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18402937 |
| http://purl.uniprot.org/uniprot/Q15418#attribution-9A7605270E7FB586DD782642234E7B06 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18402937 |
| http://purl.uniprot.org/uniprot/P01185#attribution-3D70F715891FCBE062742640398441E3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18402937 |
| http://purl.uniprot.org/uniprot/P01185#attribution-9A7605270E7FB586DD782642234E7B06 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18402937 |