| http://purl.uniprot.org/citations/18430721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18430721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18430721 | http://www.w3.org/2000/01/rdf-schema#comment | "CD147, a member of the immunoglobulin superfamily (IgSF), plays fundamental roles in intercellular interactions in numerous pathological and physiological processes. Importantly, our previous studies have demonstrated that HAb18G/CD147 is a novel hepatocellular carcinoma (HCC)-associated antigen, and HAb18G/CD147 stimulates adjacent fibroblasts and HCC cells to produce elevated levels of several matrix metalloproteinases, facilitating invasion and metastasis of HCC cells. In addition, HAb18G/CD147 has also been shown to be a novel universal cancer biomarker for diagnosis and prognostic assessment of a wide range of cancers. However, the structural basis underlying the multifunctional character of CD147 remains unresolved. We report here the crystal structure of the extracellular portion of HAb18G/CD147 at 2.8A resolution. The structure comprises an N-terminal IgC2 domain and a C-terminal IgI domain, which are connected by a 5-residue flexible linker. This unique C2-I domain organization is distinct from those of other IgSF members. Four homophilic dimers exist in the crystal and adopt C2-C2 and C2-I dimerization rather than V-V dimerization commonly found in other IgSF members. This type of homophilic association thus presents a novel model for homophilic interaction between C2 domains of IgSF members. Moreover, the crystal structure of HAb18G/CD147 provides a good structural explanation for the established multifunction of CD147 mediated by homo/hetero-oligomerizations and should represent a general architecture of other CD147 family members."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m802694200"xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m802694200"xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Jiang H."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Jiang H."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Zhu P."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Zhu P."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Yang B."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Yang B."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Hu T."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Hu T."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Shen X."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Shen X."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Chen Z.-N."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Chen Z.-N."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Ding J.-P."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Ding J.-P."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Du J.-M."xsd:string |
| http://purl.uniprot.org/citations/18430721 | http://purl.uniprot.org/core/author | "Du J.-M."xsd:string |