| http://purl.uniprot.org/citations/18468488 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18468488 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18468488 | http://www.w3.org/2000/01/rdf-schema#comment | "The T-cell co-receptor cytotoxic T-cell antigen 4 (CTLA-4) has a strong inhibitory role as shown by the lymphoproliferative phenotype of CTLA-4-deficient mice. Despite its potent effects on T-cell function, CTLA-4 is primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation. Recently, several signalling molecules such as Trim, PLD, ARF-1 and TIRC7 have been described to be involved in the transport of CTLA-4 to the cell surface. Minor changes in surface expression levels have major effects on the outcome of T-cell activation. Optimal regulation of CTLA-4 surface expression is crucial for the balance of stimulatory and inhibitory signals to maximize protective immune responses while maintaining immunological tolerance and preventing autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/18468488 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.it.2008.02.011"xsd:string |
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| http://purl.uniprot.org/citations/18468488 | http://purl.uniprot.org/core/author | "Schneider H."xsd:string |
| http://purl.uniprot.org/citations/18468488 | http://purl.uniprot.org/core/author | "Schneider H."xsd:string |
| http://purl.uniprot.org/citations/18468488 | http://purl.uniprot.org/core/author | "Valk E."xsd:string |
| http://purl.uniprot.org/citations/18468488 | http://purl.uniprot.org/core/author | "Valk E."xsd:string |
| http://purl.uniprot.org/citations/18468488 | http://purl.uniprot.org/core/author | "Rudd C.E."xsd:string |
| http://purl.uniprot.org/citations/18468488 | http://purl.uniprot.org/core/author | "Rudd C.E."xsd:string |
| http://purl.uniprot.org/citations/18468488 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18468488 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18468488 | http://purl.uniprot.org/core/name | "Trends Immunol."xsd:string |
| http://purl.uniprot.org/citations/18468488 | http://purl.uniprot.org/core/name | "Trends Immunol."xsd:string |
| http://purl.uniprot.org/citations/18468488 | http://purl.uniprot.org/core/pages | "272-279"xsd:string |
| http://purl.uniprot.org/citations/18468488 | http://purl.uniprot.org/core/pages | "272-279"xsd:string |
| http://purl.uniprot.org/citations/18468488 | http://purl.uniprot.org/core/title | "CTLA-4 trafficking and surface expression."xsd:string |
| http://purl.uniprot.org/citations/18468488 | http://purl.uniprot.org/core/title | "CTLA-4 trafficking and surface expression."xsd:string |
| http://purl.uniprot.org/citations/18468488 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/18468488 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/18468488 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18468488 |
| http://purl.uniprot.org/citations/18468488 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18468488 |
| http://purl.uniprot.org/citations/18468488 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18468488 |
| http://purl.uniprot.org/citations/18468488 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18468488 |