| http://purl.uniprot.org/citations/1849646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1849646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1849646 | http://www.w3.org/2000/01/rdf-schema#comment | "By screening a cDNA library derived from the A10 rat vascular smooth muscle cell line for functional expression in COS cells, we have isolated a high-affinity receptor for endothelin 1 (Kd = 476 pM) and endothelin 2. The affinity of the cloned endothelin receptor for endothelin 3 is greater than 100 times less in A10 cells and in a CHO cell line stably transformed by the endothelin receptor cDNA. The 426-amino acid receptor polypeptide has seven putative hydrophobic transmembrane domains and is presumed to be a member of the family of guanine nucleotide-binding regulatory (G) protein-coupled receptors. Microinjection of in vitro transcripts of the cloned cDNA into CHO cells confers a transient increase in intracellular calcium in response to endothelin 1, indicating that the receptor is functional and couples to the appropriate G protein(s). RNA analysis reveals high expression in rat lung and heart, tissues known to exhibit binding to iodinated endothelin 1."xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.88.8.3185"xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.88.8.3185"xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/author | "Lodish H.F."xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/author | "Lodish H.F."xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/author | "Lin H.Y."xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/author | "Lin H.Y."xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/author | "Kaji E.H."xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/author | "Kaji E.H."xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/author | "Ives H.E."xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/author | "Ives H.E."xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/author | "Winkel G.K."xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/author | "Winkel G.K."xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/pages | "3185-3189"xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/pages | "3185-3189"xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/title | "Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor."xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/title | "Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor."xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/1849646 | http://purl.uniprot.org/core/volume | "88"xsd:string |