| http://purl.uniprot.org/citations/18499799 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18499799 | http://www.w3.org/2000/01/rdf-schema#comment | "The 2D IR spectra of the amide-I vibrations of amyloid fibrils from Abeta40 were obtained. The matured fibrils formed from strands having isotopic substitution by (13)C (18)O at Gly-38, Gly-33, Gly-29, or Ala-21 show vibrational exciton spectra having reduced dimensionality. Indeed, linear chain excitons of amide units are seen, for which the interamide vibrational coupling is measured in fibrils grown from 50% and 5% mixtures of labeled and unlabeled strands. The data prove that the 1D excitons are formed from parallel in-register sheets. The coupling constants show that for each of the indicated residues the amide carbonyls in the chains are separated by 0.5 +/-0.05 nm. The isotope replacement of Gly-25 does not reveal linear excitons, consistent with the region of the strand having a different structure distribution. The vibrational frequencies of the amide-I modes, freed from effects of amide vibrational excitation exchange by 5% dilution experiments, point to there being a component of an electric field along the fibril axis that increases through the sequence Gly-38, Gly-33, Gly-29. The field is dominated by side chains of neighboring residues."xsd:string |
| http://purl.uniprot.org/citations/18499799 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0802993105"xsd:string |
| http://purl.uniprot.org/citations/18499799 | http://purl.uniprot.org/core/author | "Kim Y.S."xsd:string |
| http://purl.uniprot.org/citations/18499799 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/18499799 | http://purl.uniprot.org/core/author | "Axelsen P.H."xsd:string |
| http://purl.uniprot.org/citations/18499799 | http://purl.uniprot.org/core/author | "Hochstrasser R.M."xsd:string |
| http://purl.uniprot.org/citations/18499799 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18499799 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/18499799 | http://purl.uniprot.org/core/pages | "7720-7725"xsd:string |
| http://purl.uniprot.org/citations/18499799 | http://purl.uniprot.org/core/title | "Two-dimensional infrared spectra of isotopically diluted amyloid fibrils from Abeta40."xsd:string |
| http://purl.uniprot.org/citations/18499799 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/18499799 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18499799 |
| http://purl.uniprot.org/citations/18499799 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18499799 |
| http://purl.uniprot.org/uniprot/P05067#attribution-7810C0C2F32D1079DF0D0206078852BA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18499799 |