| http://purl.uniprot.org/citations/18500339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18500339 | http://www.w3.org/2000/01/rdf-schema#comment | "Separation of duplicated centrosomes (spindle-pole bodies or SPBs in yeast) is a crucial step in the biogenesis of the mitotic spindle. In vertebrates, centrosome separation requires the BimC family kinesin Eg5 and the activities of Cdk1 and polo kinase; however, the roles of these kinases are not fully understood. In Saccharomyces cerevisiae, SPB separation also requires activated Cdk1 and the plus-end kinesins Cin8 (homologous to vertebrate Eg5) and Kip1. Here we report that polo kinase has a role in the separation of SPBs. We show that adequate accumulation of Cin8 and Kip1 requires inactivation of the anaphase-promoting complex-activator Cdh1 through sequential phosphorylation by Cdk1 and polo kinase. In this process, Cdk1 functions as a priming kinase in that Cdk1-mediated phosphorylation creates a binding site for polo kinase,which further phosphorylates Cdh1. Thus, Cdh1 inactivation through the synergistic action of Cdk1 and polo kinase provides a new model for inactivation of cell-cycle effectors."xsd:string |
| http://purl.uniprot.org/citations/18500339 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1729"xsd:string |
| http://purl.uniprot.org/citations/18500339 | http://purl.uniprot.org/core/author | "Winey M."xsd:string |
| http://purl.uniprot.org/citations/18500339 | http://purl.uniprot.org/core/author | "Giddings T.H. Jr."xsd:string |
| http://purl.uniprot.org/citations/18500339 | http://purl.uniprot.org/core/author | "Lim H.H."xsd:string |
| http://purl.uniprot.org/citations/18500339 | http://purl.uniprot.org/core/author | "Surana U."xsd:string |
| http://purl.uniprot.org/citations/18500339 | http://purl.uniprot.org/core/author | "Crasta K."xsd:string |
| http://purl.uniprot.org/citations/18500339 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18500339 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/18500339 | http://purl.uniprot.org/core/pages | "665-675"xsd:string |
| http://purl.uniprot.org/citations/18500339 | http://purl.uniprot.org/core/title | "Inactivation of Cdh1 by synergistic action of Cdk1 and polo kinase is necessary for proper assembly of the mitotic spindle."xsd:string |
| http://purl.uniprot.org/citations/18500339 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/18500339 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18500339 |
| http://purl.uniprot.org/citations/18500339 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18500339 |
| http://purl.uniprot.org/uniprot/P32562#attribution-793F9BF6B4AB77AEDCFC8BE00BE35B1C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18500339 |
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| http://purl.uniprot.org/uniprot/#_P32562-mappedCitation-18500339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18500339 |
| http://purl.uniprot.org/uniprot/#_P53197-mappedCitation-18500339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18500339 |
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