| http://purl.uniprot.org/citations/18501882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18501882 | http://www.w3.org/2000/01/rdf-schema#comment | "The T-cell cytokine IL-17 is implicated in multiple inflammatory diseases through its induction of several pro-inflammatory cytokines and chemokines in a broad range of cell targets. Production of IL-17 defines the Th17 subset of helper T-cells associated with protection against microorganisms, a profile best characterized in the murine system. Multiple regulators of Th17 cell differentiation and IL-17 production are reported, but the impact of OX40L is not described. OX40 ligand (OX40L) is an early-stage activator of T-cells through its interaction with CD134 (OX40) that is up-regulated on antigen challenged T-cells. Here, we show that OX40L suppresses IL-17 production by PHA-stimulated human PBMC and purified CD4 and CD8 cells. In agreement with prior reports, OX40L signaling through CD134 increased IFNgamma and IL-4, both of which are reported to inhibit the production of IL-17. OX40L suppression of IL-17 was completely reversed by a neutralizing IFNgamma antibody while there was no effect with a neutralizing IL-4 antibody. Moreover, OX40L also suppressed IL-17 in the presence of IL-23, an established inducer of IL-17 and differentiation factor for Th17 cells. Presuming mediation by IFNgamma, we evaluated expression of this cytokine in the presence of OX40L and IL-23. Surprisingly, IL-23 also induced IFNgamma by PHA-stimulated T-cells and this effect was enhanced in the presence of OX40L. Addition of the IFNgamma antibody not only reversed the OX40L suppression of IL-17 in the presence of IL-23, it markedly enhanced the level of IL-17. These results further establish IFNgamma as a primary modulator of IL-17 production in the human cells, much as in the murine system."xsd:string |
| http://purl.uniprot.org/citations/18501882 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellimm.2008.04.010"xsd:string |
| http://purl.uniprot.org/citations/18501882 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/18501882 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/18501882 | http://purl.uniprot.org/core/author | "Benson J."xsd:string |
| http://purl.uniprot.org/citations/18501882 | http://purl.uniprot.org/core/author | "Sweet R."xsd:string |
| http://purl.uniprot.org/citations/18501882 | http://purl.uniprot.org/core/author | "Shang X."xsd:string |
| http://purl.uniprot.org/citations/18501882 | http://purl.uniprot.org/core/author | "Orlovsky Y."xsd:string |
| http://purl.uniprot.org/citations/18501882 | http://purl.uniprot.org/core/author | "Bracht M."xsd:string |
| http://purl.uniprot.org/citations/18501882 | http://purl.uniprot.org/core/author | "Merle Elloso M."xsd:string |
| http://purl.uniprot.org/citations/18501882 | http://purl.uniprot.org/core/author | "Schantz A."xsd:string |
| http://purl.uniprot.org/citations/18501882 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18501882 | http://purl.uniprot.org/core/name | "Cell Immunol"xsd:string |
| http://purl.uniprot.org/citations/18501882 | http://purl.uniprot.org/core/pages | "31-37"xsd:string |
| http://purl.uniprot.org/citations/18501882 | http://purl.uniprot.org/core/title | "Negative regulation of IL-17 production by OX40/OX40L interaction."xsd:string |
| http://purl.uniprot.org/citations/18501882 | http://purl.uniprot.org/core/volume | "253"xsd:string |
| http://purl.uniprot.org/citations/18501882 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18501882 |
| http://purl.uniprot.org/citations/18501882 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18501882 |
| http://purl.uniprot.org/uniprot/P01579#attribution-FF266EA7EFE73C5C15929079D415BEED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18501882 |
| http://purl.uniprot.org/uniprot/P23510#attribution-FF266EA7EFE73C5C15929079D415BEED | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18501882 |
| http://purl.uniprot.org/uniprot/#_D9MX03-mappedCitation-18501882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18501882 |
| http://purl.uniprot.org/uniprot/#_A0A024R937-mappedCitation-18501882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18501882 |
| http://purl.uniprot.org/uniprot/#_Q5QEX9-mappedCitation-18501882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18501882 |
| http://purl.uniprot.org/uniprot/#_Q16552-mappedCitation-18501882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18501882 |