| http://purl.uniprot.org/citations/18703708 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18703708 | http://www.w3.org/2000/01/rdf-schema#comment | "During synaptic vesicle fusion, the soluble N-ethylmaleimide-sensitive factor-attachment protein receptor (SNARE) protein syntaxin-1 exhibits two conformations that both bind to Munc18-1: a "closed" conformation outside the SNARE complex and an "open" conformation in the SNARE complex. Although SNARE complexes containing open syntaxin-1 and Munc18-1 are essential for exocytosis, the function of closed syntaxin-1 is unknown. We generated knockin/knockout mice that expressed only open syntaxin-1B. Syntaxin-1B(Open) mice were viable but succumbed to generalized seizures at 2 to 3 months of age. Binding of Munc18-1 to syntaxin-1 was impaired in syntaxin-1B(Open) synapses, and the size of the readily releasable vesicle pool was decreased; however, the rate of synaptic vesicle fusion was dramatically enhanced. Thus, the closed conformation of syntaxin-1 gates the initiation of the synaptic vesicle fusion reaction, which is then mediated by SNARE-complex/Munc18-1 assemblies."xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1163174"xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://purl.uniprot.org/core/author | "Hammer R.E."xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://purl.uniprot.org/core/author | "Sudhof T.C."xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://purl.uniprot.org/core/author | "Dulubova I."xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://purl.uniprot.org/core/author | "Rizo J."xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://purl.uniprot.org/core/author | "Meyer A.C."xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://purl.uniprot.org/core/author | "Rosenmund C."xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://purl.uniprot.org/core/author | "Verhage M."xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://purl.uniprot.org/core/author | "Min S.W."xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://purl.uniprot.org/core/author | "Gerber S.H."xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://purl.uniprot.org/core/author | "de Wit H."xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://purl.uniprot.org/core/author | "Rah J.C."xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://purl.uniprot.org/core/author | "Arancillo M."xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18703708 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://purl.uniprot.org/core/pages | "1507-1510"xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://purl.uniprot.org/core/title | "Conformational switch of syntaxin-1 controls synaptic vesicle fusion."xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://purl.uniprot.org/core/volume | "321"xsd:string |
| http://purl.uniprot.org/citations/18703708 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18703708 |
| http://purl.uniprot.org/citations/18703708 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18703708 |
| http://purl.uniprot.org/uniprot/P60879#attribution-A463F719290A2DEB654ED2FD4D6CCA9F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18703708 |
| http://purl.uniprot.org/uniprot/P32851#attribution-1F42904B94AE7CB7DC74BFBAE81239D1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18703708 |