| http://purl.uniprot.org/citations/18829533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18829533 | http://www.w3.org/2000/01/rdf-schema#comment | "The origin of tumor heterogeneity is poorly understood, yet it represents a major barrier to effective therapy. In melanoma and in melanocyte development, the microphthalmia-associated transcription factor (Mitf) controls survival, differentiation, proliferation, and migration/metastasis. The Brn-2 (N-Oct-3, POU3F2) transcription factor also regulates melanoma proliferation and is up-regulated by BRAF and beta-catenin, two key melanoma-associated signaling molecules. Here, we show that Brn-2 also regulates invasiveness and directly represses Mitf expression. Remarkably, in melanoma biopsies, Mitf and Brn-2 each mark a distinct subpopulation of melanoma cells, providing a striking illustration of melanoma tumor heterogeneity with implications for melanoma therapy."xsd:string |
| http://purl.uniprot.org/citations/18829533 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-08-1053"xsd:string |
| http://purl.uniprot.org/citations/18829533 | http://purl.uniprot.org/core/author | "Davidson I."xsd:string |
| http://purl.uniprot.org/citations/18829533 | http://purl.uniprot.org/core/author | "Goodall J."xsd:string |
| http://purl.uniprot.org/citations/18829533 | http://purl.uniprot.org/core/author | "Goding C.R."xsd:string |
| http://purl.uniprot.org/citations/18829533 | http://purl.uniprot.org/core/author | "Nuciforo P."xsd:string |
| http://purl.uniprot.org/citations/18829533 | http://purl.uniprot.org/core/author | "Denat L."xsd:string |
| http://purl.uniprot.org/citations/18829533 | http://purl.uniprot.org/core/author | "Larue L."xsd:string |
| http://purl.uniprot.org/citations/18829533 | http://purl.uniprot.org/core/author | "Carreira S."xsd:string |
| http://purl.uniprot.org/citations/18829533 | http://purl.uniprot.org/core/author | "Sturm R.A."xsd:string |
| http://purl.uniprot.org/citations/18829533 | http://purl.uniprot.org/core/author | "Kobi D."xsd:string |
| http://purl.uniprot.org/citations/18829533 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18829533 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/18829533 | http://purl.uniprot.org/core/pages | "7788-7794"xsd:string |
| http://purl.uniprot.org/citations/18829533 | http://purl.uniprot.org/core/title | "Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells."xsd:string |
| http://purl.uniprot.org/citations/18829533 | http://purl.uniprot.org/core/volume | "68"xsd:string |
| http://purl.uniprot.org/citations/18829533 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18829533 |
| http://purl.uniprot.org/citations/18829533 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18829533 |
| http://purl.uniprot.org/uniprot/#_A0A087WXU1-mappedCitation-18829533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18829533 |
| http://purl.uniprot.org/uniprot/#_A0A0H3W5T2-mappedCitation-18829533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18829533 |
| http://purl.uniprot.org/uniprot/#_A0A8F9W6H4-mappedCitation-18829533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18829533 |
| http://purl.uniprot.org/uniprot/#_A0A0A7NWS7-mappedCitation-18829533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18829533 |
| http://purl.uniprot.org/uniprot/#_B4DNC7-mappedCitation-18829533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18829533 |
| http://purl.uniprot.org/uniprot/#_A8K5K3-mappedCitation-18829533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/18829533 |