| http://purl.uniprot.org/citations/18829537 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18829537 | http://www.w3.org/2000/01/rdf-schema#comment | "The genes encoding Slits and their Robo receptors are silenced in many types of cancer, including breast, suggesting a role for this signaling pathway in suppressing tumorigenesis. The molecular mechanism underlying these tumor-suppressive effects has not been delineated. Here, we show that loss of Slits, or their Robo1 receptor, in murine mammary gland or human breast carcinoma cells results in coordinate up-regulation of the Sdf1 and Cxcr4 signaling axis, specifically within mammary epithelium. This is accompanied by hyperplastic changes in cells and desmoplastic alterations in the surrounding stroma. A similar inverse correlation between Slit and Cxcr4 expression is identified in human breast tumor tissues. Furthermore, we show in a xenograft model that Slit overexpression down-regulates CXCR4 and dominantly suppresses tumor growth. These studies classify Slits as negative regulators of Sdf1 and Cxcr4 and identify a molecular signature in hyperplastic breast lesions that signifies inappropriate up-regulation of key prometastatic genes."xsd:string |
| http://purl.uniprot.org/citations/18829537 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-08-1357"xsd:string |
| http://purl.uniprot.org/citations/18829537 | http://purl.uniprot.org/core/author | "Lee J.S."xsd:string |
| http://purl.uniprot.org/citations/18829537 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/18829537 | http://purl.uniprot.org/core/author | "Cardiff R.D."xsd:string |
| http://purl.uniprot.org/citations/18829537 | http://purl.uniprot.org/core/author | "Sukumar S."xsd:string |
| http://purl.uniprot.org/citations/18829537 | http://purl.uniprot.org/core/author | "Macias H."xsd:string |
| http://purl.uniprot.org/citations/18829537 | http://purl.uniprot.org/core/author | "Hinck L."xsd:string |
| http://purl.uniprot.org/citations/18829537 | http://purl.uniprot.org/core/author | "Moran A."xsd:string |
| http://purl.uniprot.org/citations/18829537 | http://purl.uniprot.org/core/author | "Marlow R."xsd:string |
| http://purl.uniprot.org/citations/18829537 | http://purl.uniprot.org/core/author | "Strickland P."xsd:string |
| http://purl.uniprot.org/citations/18829537 | http://purl.uniprot.org/core/author | "Binnewies M."xsd:string |
| http://purl.uniprot.org/citations/18829537 | http://purl.uniprot.org/core/author | "Le E.K."xsd:string |
| http://purl.uniprot.org/citations/18829537 | http://purl.uniprot.org/core/author | "Pebenito M."xsd:string |
| http://purl.uniprot.org/citations/18829537 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18829537 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/18829537 | http://purl.uniprot.org/core/pages | "7819-7827"xsd:string |
| http://purl.uniprot.org/citations/18829537 | http://purl.uniprot.org/core/title | "SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium."xsd:string |
| http://purl.uniprot.org/citations/18829537 | http://purl.uniprot.org/core/volume | "68"xsd:string |
| http://purl.uniprot.org/citations/18829537 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/18829537 |
| http://purl.uniprot.org/citations/18829537 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/18829537 |
| http://purl.uniprot.org/uniprot/O89026#attribution-AB7C46B573330014C3F828E924F9E044 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18829537 |
| http://purl.uniprot.org/uniprot/Q9Y6N7#attribution-202B9E3D324AB99A9C86814F4A4B5B24 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18829537 |
| http://purl.uniprot.org/uniprot/O75094#attribution-202B9E3D324AB99A9C86814F4A4B5B24 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/18829537 |