| http://purl.uniprot.org/citations/18838382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18838382 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the Fgd (faciogenital dysplasia) gene family encode a group of critical guanine nucleotide exchange factors (GEFs), which, by specifically activating Cdc42, control cytoskeleton-dependent membrane rearrangements. In its first characterization, we find that FGD2 is expressed in antigen-presenting cells, including B lymphocytes, macrophages, and dendritic cells. In the B lymphocyte lineage, FGD2 levels change with developmental stage. In both mature splenic B cells and immature bone marrow B cells, FGD2 expression is suppressed upon activation through the B cell antigen receptor. FGD2 has a complex intracellular localization, with concentrations found in membrane ruffles and early endosomes. Although endosomal localization of FGD2 is dependent on a conserved FYVE domain, its C-terminal pleckstrin homology domain mediates recruitment to membrane ruffles. FGD2 overexpression promotes the activation of Cdc42 and leads to elevated JNK1 activity in a Cdc42-but not Rac1-dependent fashion. These findings are consistent with a role of FGD2 in leukocyte signaling and vesicle trafficking in cells specialized to present antigen in the immune system."xsd:string |
| http://purl.uniprot.org/citations/18838382 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m803957200"xsd:string |
| http://purl.uniprot.org/citations/18838382 | http://purl.uniprot.org/core/author | "Bokoch G.M."xsd:string |
| http://purl.uniprot.org/citations/18838382 | http://purl.uniprot.org/core/author | "Nemazee D."xsd:string |
| http://purl.uniprot.org/citations/18838382 | http://purl.uniprot.org/core/author | "Huber C."xsd:string |
| http://purl.uniprot.org/citations/18838382 | http://purl.uniprot.org/core/author | "Gavin A.L."xsd:string |
| http://purl.uniprot.org/citations/18838382 | http://purl.uniprot.org/core/author | "Martensson A."xsd:string |
| http://purl.uniprot.org/citations/18838382 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18838382 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/18838382 | http://purl.uniprot.org/core/pages | "34002-34012"xsd:string |
| http://purl.uniprot.org/citations/18838382 | http://purl.uniprot.org/core/title | "FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles."xsd:string |
| http://purl.uniprot.org/citations/18838382 | http://purl.uniprot.org/core/volume | "283"xsd:string |
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