| http://purl.uniprot.org/citations/18851979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18851979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18851979 | http://www.w3.org/2000/01/rdf-schema#comment | "RBBP6 (retinoblastoma binding protein 6) is a 250-kDa multifunctional protein that interacts with both p53 and pRb and has been implicated in mRNA processing. It has also been identified as a putative E3 ubiquitin ligase due to the presence of a RING finger domain, although no substrate has been identified up to now. Using the RING finger domain as bait in a yeast two-hybrid screen, we identified YB-1 (Y-box binding protein 1) as a binding partner of RBBP6, localising the interaction to the last 62 residues of YB-1. We showed, furthermore, that both full-length RBBP6 and the isolated RING finger domain were able to ubiquitinate YB-1, resulting in its degradation in the proteosome. As a result, RBBP6 was able to suppress the levels of YB-1 in vivo and to reduce its transactivational ability. In the light of the important role that YB-1 appears to play in tumourigenesis, our results suggest that RBBP6 may be a relevant target for therapeutic drugs aimed at modifying the activity of YB-1."xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2008.09.060"xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2008.09.060"xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/author | "Meyer M."xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/author | "Meyer M."xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/author | "Rees D.J.G."xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/author | "Rees D.J.G."xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/author | "Pugh D.J."xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/author | "Pugh D.J."xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/author | "Chibi M."xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/author | "Chibi M."xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/author | "Moolman-Smook J.C."xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/author | "Moolman-Smook J.C."xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/author | "Skepu A."xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/author | "Skepu A."xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/pages | "908-916"xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/pages | "908-916"xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/title | "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1."xsd:string |
| http://purl.uniprot.org/citations/18851979 | http://purl.uniprot.org/core/title | "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1."xsd:string |