| http://purl.uniprot.org/citations/18953350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18953350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18953350 | http://www.w3.org/2000/01/rdf-schema#comment | "The major known genetic risk factors in multiple sclerosis reside in the major histocompatibility complex (MHC) region. Although there is strong evidence implicating MHC class II alleles and CD4(+) T cells in multiple sclerosis pathogenesis, possible contributions from MHC class I genes and CD8(+) T cells are controversial. We have generated humanized mice expressing the multiple sclerosis-associated MHC class I alleles HLA-A(*)0301 (encoding human leukocyte antigen-A3 (HLA-A3)) and HLA-A(*)0201 (encoding HLA-A2) and a myelin-specific autoreactive T cell receptor (TCR) derived from a CD8(+) T cell clone from an individual with multiple sclerosis to study mechanisms of disease susceptibility. We demonstrate roles for HLA-A3-restricted CD8(+) T cells in induction of multiple sclerosis-like disease and for CD4(+) T cells in its progression, and we also define a possible mechanism for HLA-A(*)0201-mediated protection. To our knowledge, these data provide the first direct evidence incriminating MHC class I genes and CD8(+) T cells in the pathogenesis of human multiple sclerosis and reveal a network of MHC interactions that shape the risk of multiple sclerosis."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.1881"xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.1881"xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Bell J.I."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Bell J.I."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Fugger L."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Fugger L."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Jones E.Y."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Jones E.Y."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Friese M.A."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Friese M.A."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Jensen L.T."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Jensen L.T."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Etzensperger R."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Etzensperger R."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Craner M.J."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Craner M.J."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Friis L."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Friis L."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Huygelen V."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Huygelen V."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Jakobsen K.B."xsd:string |
| http://purl.uniprot.org/citations/18953350 | http://purl.uniprot.org/core/author | "Jakobsen K.B."xsd:string |