| http://purl.uniprot.org/citations/18988763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/18988763 | http://www.w3.org/2000/01/rdf-schema#comment | "Tendon tissue and the extracellular matrix of skeletal muscle respond to mechanical loading by increased collagen expression and synthesis. This response is likely a secondary effect of a mechanically induced expression of growth factors, including transforming growth factor-beta1 (TGF-beta1) and insulin-like growth factor-I (IGF-I). It is not known whether unloading of tendon tissue can reduce the expression of collagen and collagen-inducing growth factors. Furthermore, the coordinated response of tendon and muscle tissue to disuse, followed by reloading, is unclear. Female Sprague-Dawley rats were subjected to hindlimb suspension (HS) for 7 or 14 days, followed by 2, 4, 8, or 16 days of reload (RL) (n = 8 in each group). Age-matched controls were included for day 0, day 14 HS, and day 16 RL (n = 8). mRNA expression levels for collagen I (COL1A1), collagen III (COL3A1), TGF-beta1, connective tissue growth factor (CTGF), myostatin, and IGF-I isoforms were measured by real-time RT-PCR in Achilles tendon and soleus muscle. The tendon mass was unchanged, while the muscle mass was reduced by 50% after HS (P < 0.05) and returned to control levels during RL. Collagen I and III, TGF-beta1, and CTGF mRNA levels were unaltered by HS, although collagen III tended to decrease in muscle at day 7 HS. IGF-I isoforms were significantly induced in tendon after 7 days of HS (P < 0.001), and mechanogrowth factor increased in muscle at day 14 HS (P < 0.05). Reload increased muscle collagen I and III mRNA (>10-fold) (P < 0.001) and growth factor expression (P < 0.05), while the tendon response was limited to a moderate induction of collagen expression (2-fold) (P < 0.05). Unloading of tendon and muscle tissue did not reduce expression of collagen and collagen-inducing growth factors, indicating that the response to unloading is not opposite that of loading. Furthermore, the tendon response was clearly different and less pronounced than the muscle tissue response."xsd:string |
| http://purl.uniprot.org/citations/18988763 | http://purl.org/dc/terms/identifier | "doi:10.1152/japplphysiol.91092.2008"xsd:string |
| http://purl.uniprot.org/citations/18988763 | http://purl.uniprot.org/core/author | "Schjerling P."xsd:string |
| http://purl.uniprot.org/citations/18988763 | http://purl.uniprot.org/core/author | "Kjaer M."xsd:string |
| http://purl.uniprot.org/citations/18988763 | http://purl.uniprot.org/core/author | "Haddad F."xsd:string |
| http://purl.uniprot.org/citations/18988763 | http://purl.uniprot.org/core/author | "Baldwin K.M."xsd:string |
| http://purl.uniprot.org/citations/18988763 | http://purl.uniprot.org/core/author | "Heinemeier K.M."xsd:string |
| http://purl.uniprot.org/citations/18988763 | http://purl.uniprot.org/core/author | "Olesen J.L."xsd:string |
| http://purl.uniprot.org/citations/18988763 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/18988763 | http://purl.uniprot.org/core/name | "J Appl Physiol (1985)"xsd:string |
| http://purl.uniprot.org/citations/18988763 | http://purl.uniprot.org/core/pages | "178-186"xsd:string |
| http://purl.uniprot.org/citations/18988763 | http://purl.uniprot.org/core/title | "Effect of unloading followed by reloading on expression of collagen and related growth factors in rat tendon and muscle."xsd:string |
| http://purl.uniprot.org/citations/18988763 | http://purl.uniprot.org/core/volume | "106"xsd:string |
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