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Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain.

Faure-Andre G., Vargas P., Yuseff M.I., Heuze M., Diaz J., Lankar D., Steri V., Manry J., Hugues S., Vascotto F., Boulanger J., Raposo G., Bono M.R., Rosemblatt M., Piel M., Lennon-Dumenil A.M.

Dendritic cells (DCs) sample peripheral tissues of the body in search of antigens to present to T cells. This requires two processes, antigen processing and cell motility, originally thought to occur independently. We found that the major histocompatibility complex II-associated invariant chain (Ii or CD74), a known regulator of antigen processing, negatively regulates DC motility in vivo. By using microfabricated channels to mimic the confined environment of peripheral tissues, we found that wild-type DCs alternate between high and low motility, whereas Ii-deficient cells moved in a faster and more uniform manner. The regulation of cell motility by Ii depended on the actin-based motor protein myosin II. Coupling antigen processing and cell motility may enable DCs to more efficiently detect and process antigens within a defined space.

Science 322:1705-1710(2008) [PubMed] [Europe PMC]

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