| http://purl.uniprot.org/citations/19078957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19078957 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19078957 | http://www.w3.org/2000/01/rdf-schema#comment | "BRAF and NRAS are common targets for somatic mutations in benign and malignant neoplasms that arise from melanocytes situated in epithelial structures, and lead to constitutive activation of the mitogen-activated protein (MAP) kinase pathway. However, BRAF and NRAS mutations are absent in a number of other melanocytic neoplasms in which the equivalent oncogenic events are currently unknown. Here we report frequent somatic mutations in the heterotrimeric G protein alpha-subunit, GNAQ, in blue naevi (83%) and ocular melanoma of the uvea (46%). The mutations occur exclusively in codon 209 in the Ras-like domain and result in constitutive activation, turning GNAQ into a dominant acting oncogene. Our results demonstrate an alternative route to MAP kinase activation in melanocytic neoplasia, providing new opportunities for therapeutic intervention."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature07586"xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature07586"xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/author | "Bauer J."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/author | "Bauer J."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/author | "Green G."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/author | "Green G."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/author | "Barsh G.S."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/author | "Barsh G.S."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/author | "Simpson E.M."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/author | "Simpson E.M."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/author | "Bastian B.C."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/author | "Bastian B.C."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/author | "O'Brien J.M."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/author | "O'Brien J.M."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/author | "Bezrookove V."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/author | "Bezrookove V."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/author | "Gaugler L."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/author | "Gaugler L."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/author | "Van Raamsdonk C.D."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/author | "Van Raamsdonk C.D."xsd:string |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19078957 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |