| http://purl.uniprot.org/citations/19088079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19088079 | http://www.w3.org/2000/01/rdf-schema#comment | "The platelet-derived growth factor (PDGF) signaling pathway is a critical regulator of animal development and homeostasis. Activation of the PDGF pathway leads to neointimal proliferative responses to artery injury; it promotes a switch of vascular smooth muscle cells (vSMC) to a less contractile phenotype by inhibiting the SMC-specific gene expression and increasing the rate of proliferation and migration. The molecular mechanism for these pleiotropic effects of PDGFs has not been fully described. Here, we identify the microRNA-221 (miR-221), a small noncoding RNA, as a modulator of the phenotypic change of vSMCs in response to PDGF signaling. We demonstrate that miR-221 is transcriptionally induced upon PDGF treatment in primary vSMCs, leading to down-regulation of the targets c-Kit and p27Kip1. Down-regulation of p27Kip1 by miR-221 is critical for PDGF-mediated induction of cell proliferation. Additionally, decreased c-Kit causes inhibition of SMC-specific contractile gene transcription by reducing the expression of Myocardin (Myocd), a potent SMC-specific nuclear coactivator. Our study demonstrates that PDGF signaling, by modulating the expression of miR-221, regulates two critical determinants of the vSMC phenotype; they are SMC gene expression and cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/19088079 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m808788200"xsd:string |
| http://purl.uniprot.org/citations/19088079 | http://purl.uniprot.org/core/author | "Hata A."xsd:string |
| http://purl.uniprot.org/citations/19088079 | http://purl.uniprot.org/core/author | "Nguyen P.H."xsd:string |
| http://purl.uniprot.org/citations/19088079 | http://purl.uniprot.org/core/author | "Lagna G."xsd:string |
| http://purl.uniprot.org/citations/19088079 | http://purl.uniprot.org/core/author | "Davis B.N."xsd:string |
| http://purl.uniprot.org/citations/19088079 | http://purl.uniprot.org/core/author | "Hilyard A.C."xsd:string |
| http://purl.uniprot.org/citations/19088079 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19088079 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19088079 | http://purl.uniprot.org/core/pages | "3728-3738"xsd:string |
| http://purl.uniprot.org/citations/19088079 | http://purl.uniprot.org/core/title | "Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype."xsd:string |
| http://purl.uniprot.org/citations/19088079 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19088079 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19088079 |
| http://purl.uniprot.org/citations/19088079 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19088079 |
| http://purl.uniprot.org/uniprot/P46527#attribution-582FBFE42BF225812A8EA2318F81E651 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19088079 |
| http://purl.uniprot.org/uniprot/P10721#attribution-2D28B922DF82C184248FE2BCA0215E1F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19088079 |
| http://purl.uniprot.org/uniprot/P01127#attribution-2D28B922DF82C184248FE2BCA0215E1F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19088079 |
| http://purl.uniprot.org/uniprot/#_A0A0U2N547-mappedCitation-19088079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19088079 |
| http://purl.uniprot.org/uniprot/#_A0A8I5KR87-mappedCitation-19088079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19088079 |
| http://purl.uniprot.org/uniprot/#_E2I6G0-mappedCitation-19088079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19088079 |
| http://purl.uniprot.org/uniprot/#_A7KMP4-mappedCitation-19088079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19088079 |
| http://purl.uniprot.org/uniprot/#_B6DXN3-mappedCitation-19088079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19088079 |
| http://purl.uniprot.org/uniprot/#_B6E0M6-mappedCitation-19088079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19088079 |
| http://purl.uniprot.org/uniprot/#_B4DPH2-mappedCitation-19088079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19088079 |