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Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea.

Lee K., Kim M.N., Choi T.Y., Cho S.E., Lee S., Whang D.H., Yong D., Chong Y., Woodford N., Livermore D.M., Jeong S.H., Kim M.Y., Ha G.Y., Lee W.G., Hong Y.A., Cho J.H., Uh Y., Jang S.J., Park A.J., Lee M.H., Song W., Kang J.O., Shin J.H., Hong S.G., Kim Y.A., Lee H.J., Cho D.H., Lee S.

Carbapenem-resistant Acinetobacter spp. are being increasingly reported worldwide, including in South Korea, where we examined 144 representative isolates collected in a nationwide hospital survey in 2005. Metallo-beta-lactamases were detected in only 19.4% of isolates, none of which were Acinetobacter baumannii, whereas 74.3% of isolates (mostly A. baumannii) expressed bla(OXA) carbapenemase genes. Among the latter, 47 had bla(OXA-23)-like genes and 56 had upregulated bla(OXA-51)-like variants, including bla(OXA-66), (-83), (-109) and (-115); bla(OXA-115) was a novel variant, detected in two isolates. bla(OXA-72) (bla(OXA-40)-like) was detected in only a single Acinetobacter baylyi isolate, whilst three Acinetobacter calcoaceticus isolates had both bla(VIM-2)-like and bla(OXA-58) genes. Pulsed-field gel electrophoresis (PFGE) suggested the spread of A. baumannii clones with OXA carbapenemases within and between hospitals. In conclusion, the recent increase in imipenem-resistant Acinetobacter spp. from South Korea is mostly due to OXA-type carbapenemases.

Int. J. Antimicrob. Agents 33:520-524(2009) [PubMed] [Europe PMC]

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