| http://purl.uniprot.org/citations/19111656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19111656 | http://www.w3.org/2000/01/rdf-schema#comment | "Both the POLH-1 (pol eta) translesion synthesis (TLS) DNA polymerase and the GEI-17 SUMO E3 ligase are essential for the efficient replication of damaged chromosomes in Caenorhabditis elegans embryos. Here we study how POLH-1 is regulated during a DNA-damage response in these embryos. We report that DNA damage triggers the degradation of POLH-1 and that degradation is mediated by the Cul4-Ddb1-Cdt2 (CRL4-Cdt2) pathway that has previously been shown to degrade the replication factor Cdt1 during S phase. We also show that GEI-17 protects POLH-1 from CRL4-Cdt2-mediated destruction until after it has performed its function in TLS, and this is likely via SUMOylation of POLH-1. These studies reveal that POLH-1 undergoes DNA-damage-induced proteolysis and that GEI-17 regulates the timing of this proteolysis. Implications for how this system may control the removal of POLH-1 from replication forks after TLS are discussed."xsd:string |
| http://purl.uniprot.org/citations/19111656 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2008.11.016"xsd:string |
| http://purl.uniprot.org/citations/19111656 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/19111656 | http://purl.uniprot.org/core/author | "Michael W.M."xsd:string |
| http://purl.uniprot.org/citations/19111656 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19111656 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/19111656 | http://purl.uniprot.org/core/pages | "757-766"xsd:string |
| http://purl.uniprot.org/citations/19111656 | http://purl.uniprot.org/core/title | "Regulated proteolysis of DNA polymerase eta during the DNA-damage response in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/19111656 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/19111656 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19111656 |
| http://purl.uniprot.org/citations/19111656 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19111656 |
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| http://purl.uniprot.org/uniprot/Q21554#attribution-4FF841996F6588B7F9B5FEEB9280D579 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19111656 |
| http://purl.uniprot.org/uniprot/Q94361#attribution-25EAF47458542453D7A362B33E5C57F8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19111656 |
| http://purl.uniprot.org/uniprot/Q94361#attribution-C6CF9AF5B3DBB548B7671C374A3B6CD8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19111656 |
| http://purl.uniprot.org/uniprot/O02115#attribution-F3AC31DDB0EA285595A2195964DA7D8C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19111656 |
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| http://purl.uniprot.org/uniprot/G5EFY1#attribution-C6CF9AF5B3DBB548B7671C374A3B6CD8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19111656 |
| http://purl.uniprot.org/uniprot/Q22059#attribution-25EAF47458542453D7A362B33E5C57F8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19111656 |
| http://purl.uniprot.org/uniprot/#_G5EFY1-mappedCitation-19111656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19111656 |
| http://purl.uniprot.org/uniprot/#_O02115-mappedCitation-19111656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19111656 |
| http://purl.uniprot.org/uniprot/#_Q17392-mappedCitation-19111656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19111656 |
| http://purl.uniprot.org/uniprot/#_Q21554-mappedCitation-19111656 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19111656 |