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http://purl.uniprot.org/citations/19135435http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19135435http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the roles of glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) in the pathogenesis of hepatocellular carcinoma (HCC).

Methods

The expression of the GPI-PLD in HCC was determined. The GPI-PLD gene was stably transfected in HepG2 cells and the proliferation of these cells was detected; CD55, CD59 and apoptotic cells were also analyzed.

Results

The serum GPI-PLD activities, the protein and mRNA levels of GPI-PLD in HCC patients were decreased by 40%, 60% and 56%, respectively. The killing rate of CDC against the positive clone cells was significantly increased, but the proliferative capacity was obviously decreased. The apoptotic rate in positive clones was increased.

Conclusion

The expression of GPI-PLD decreases in HCC patients. The over-expression of GPI-PLD in HepG2 cells increases their sensitivity to CDC killing, impairs proliferative capacity and promotes apoptosis."xsd:string
http://purl.uniprot.org/citations/19135435http://purl.org/dc/terms/identifier"doi:10.1016/j.clinbiochem.2008.11.019"xsd:string
http://purl.uniprot.org/citations/19135435http://purl.uniprot.org/core/author"Huang H."xsd:string
http://purl.uniprot.org/citations/19135435http://purl.uniprot.org/core/author"Duan Q."xsd:string
http://purl.uniprot.org/citations/19135435http://purl.uniprot.org/core/author"Tan C.C."xsd:string
http://purl.uniprot.org/citations/19135435http://purl.uniprot.org/core/author"Wang K.J."xsd:string
http://purl.uniprot.org/citations/19135435http://purl.uniprot.org/core/author"Yuan X.Y."xsd:string
http://purl.uniprot.org/citations/19135435http://purl.uniprot.org/core/author"Zhu X.J."xsd:string
http://purl.uniprot.org/citations/19135435http://purl.uniprot.org/core/author"Tang J.H."xsd:string
http://purl.uniprot.org/citations/19135435http://purl.uniprot.org/core/author"He W.J."xsd:string
http://purl.uniprot.org/citations/19135435http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19135435http://purl.uniprot.org/core/name"Clin Biochem"xsd:string
http://purl.uniprot.org/citations/19135435http://purl.uniprot.org/core/pages"400-407"xsd:string
http://purl.uniprot.org/citations/19135435http://purl.uniprot.org/core/title"Important roles of glycosylphosphatidylinositol (GPI)-specific phospholipase D and some GPI-anchored proteins in the pathogenesis of hepatocellular carcinoma."xsd:string
http://purl.uniprot.org/citations/19135435http://purl.uniprot.org/core/volume"42"xsd:string
http://purl.uniprot.org/citations/19135435http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19135435
http://purl.uniprot.org/citations/19135435http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19135435
http://purl.uniprot.org/uniprot/P80108#attribution-70BD78A292AC7053BAED91C57281424Dhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/19135435