| http://purl.uniprot.org/citations/19139562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19139562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19139562 | http://www.w3.org/2000/01/rdf-schema#comment | "There is an association between expression of the MHC class I molecule HLA-B27 and protection following human infection with either HIV or HCV. In both cases, protection has been linked to HLA-B27 presentation of a single immunodominant viral peptide epitope to CD8+ T cells. If HIV mutates the HLA-B27-binding anchor of this epitope to escape the protective immune response, the result is a less-fit virus that requires additional compensatory clustered mutations. Here, we sought to determine whether the immunodominant HLA-B27-restricted HCV epitope was similarly constrained by analyzing the replication competence and immunogenicity of different escape mutants. Interestingly, in most HLA-B27-positive patients chronically infected with HCV, the escape mutations spared the HLA-B27-binding anchor. Instead, the escape mutations were clustered at other sites within the epitope and had only a modest impact on replication competence. Further analysis revealed that the cluster of mutations is required for efficient escape because a combination of mutations is needed to impair T cell recognition of the epitope. Artificially introduced mutations at the HLA-B27-binding anchors were found to be either completely cross-reactive or to lead to substantial loss of fitness. These results suggest that protection by HLA-B27 in HCV infection can be explained by the requirement to accumulate a cluster of mutations within the immunodominant epitope to escape T cell recognition."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci36587"xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci36587"xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Blum H.E."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Blum H.E."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Tavis J.E."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Tavis J.E."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Shaw J."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Shaw J."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Kelleher D."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Kelleher D."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Bartenschlager R."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Bartenschlager R."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Bowness P."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Bowness P."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Bressanelli S."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Bressanelli S."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Timm J."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Timm J."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Thimme R."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Thimme R."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Rosen H.R."xsd:string |
| http://purl.uniprot.org/citations/19139562 | http://purl.uniprot.org/core/author | "Rosen H.R."xsd:string |