| http://purl.uniprot.org/citations/19141078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19141078 | http://www.w3.org/2000/01/rdf-schema#comment | "Brevican is known to be an abundant extracellular matrix component in the adult brain and a structural constituent of perineuronal nets. We herein show that brevican, tenascin-R (TN-R) and phosphacan are present at the nodes of Ranvier on myelinated axons with a particularly large diameter in the central nervous system. A brevican deficiency resulted in a reorganization of the nodal matrices, which was characterized by the shift of TN-R, and concomitantly phosphacan, from an axonal diameter-dependent association with nodes to an axonal diameter independent association. Supported by the co-immunoprecipitation results, these observations indicate that the presence of TN-R and phosphacan at nodes is normally brevican-dependent, while in the absence of brevican these molecules can also be recruited by versican V2. The versican V2 and Bral1 distribution was not affected, thus indicating a brevican-independent role of these two molecules for establishing hyaluronan-binding matrices at the nodes. Our results revealed that brevican plays a crucial role in determining the specialization of the hyaluronan-binding nodal matrix assemblies in large diameter nodes."xsd:string |
| http://purl.uniprot.org/citations/19141078 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2009.05873.x"xsd:string |
| http://purl.uniprot.org/citations/19141078 | http://purl.uniprot.org/core/author | "Ninomiya Y."xsd:string |
| http://purl.uniprot.org/citations/19141078 | http://purl.uniprot.org/core/author | "Rauch U."xsd:string |
| http://purl.uniprot.org/citations/19141078 | http://purl.uniprot.org/core/author | "Oohashi T."xsd:string |
| http://purl.uniprot.org/citations/19141078 | http://purl.uniprot.org/core/author | "Bekku Y."xsd:string |
| http://purl.uniprot.org/citations/19141078 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19141078 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/19141078 | http://purl.uniprot.org/core/pages | "1266-1276"xsd:string |
| http://purl.uniprot.org/citations/19141078 | http://purl.uniprot.org/core/title | "Brevican distinctively assembles extracellular components at the large diameter nodes of Ranvier in the CNS."xsd:string |
| http://purl.uniprot.org/citations/19141078 | http://purl.uniprot.org/core/volume | "108"xsd:string |
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