| http://purl.uniprot.org/citations/19141282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19141282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19141282 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-7 and IL-7Ralpha bind the gamma(c) receptor, forming a complex crucial to several signaling cascades leading to the development and homeostasis of T and B cells. We report that the IL-7Ralpha ectodomain uses glycosylation to modulate its binding constants to IL-7, unlike the other receptors in the gamma(c) family. IL-7 binds glycosylated IL-7Ralpha 300-fold more tightly than unglycosylated IL-7Ralpha, and the enhanced affinity is attributed primarily to an accelerated on rate. Structural comparison of IL-7 in complex to both forms of IL-7Ralpha reveals that glycosylation does not participate directly in the binding interface. The SCID mutations of IL-7Ralpha locate outside the binding interface with IL-7, suggesting that the expressed mutations cause protein folding defects in IL-7Ralpha. The IL-7/IL-7Ralpha structures provide a window into the molecular recognition events of the IL-7 signaling cascade and provide sites to target for designing new therapeutics to treat IL-7-related diseases."xsd:string |
| http://purl.uniprot.org/citations/19141282 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2008.10.019"xsd:string |
| http://purl.uniprot.org/citations/19141282 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2008.10.019"xsd:string |
| http://purl.uniprot.org/citations/19141282 | http://purl.uniprot.org/core/author | "McElroy C.A."xsd:string |
| http://purl.uniprot.org/citations/19141282 | http://purl.uniprot.org/core/author | "McElroy C.A."xsd:string |
| http://purl.uniprot.org/citations/19141282 | http://purl.uniprot.org/core/author | "Walsh S.T."xsd:string |
| http://purl.uniprot.org/citations/19141282 | http://purl.uniprot.org/core/author | "Walsh S.T."xsd:string |
| http://purl.uniprot.org/citations/19141282 | http://purl.uniprot.org/core/author | "Dohm J.A."xsd:string |
| http://purl.uniprot.org/citations/19141282 | http://purl.uniprot.org/core/author | "Dohm J.A."xsd:string |
| http://purl.uniprot.org/citations/19141282 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19141282 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19141282 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/19141282 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/19141282 | http://purl.uniprot.org/core/pages | "54-65"xsd:string |
| http://purl.uniprot.org/citations/19141282 | http://purl.uniprot.org/core/pages | "54-65"xsd:string |
| http://purl.uniprot.org/citations/19141282 | http://purl.uniprot.org/core/title | "Structural and biophysical studies of the human IL-7/IL-7Ralpha complex."xsd:string |
| http://purl.uniprot.org/citations/19141282 | http://purl.uniprot.org/core/title | "Structural and biophysical studies of the human IL-7/IL-7Ralpha complex."xsd:string |
| http://purl.uniprot.org/citations/19141282 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/19141282 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/19141282 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19141282 |
| http://purl.uniprot.org/citations/19141282 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19141282 |
| http://purl.uniprot.org/citations/19141282 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19141282 |
| http://purl.uniprot.org/citations/19141282 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19141282 |