| http://purl.uniprot.org/citations/19142223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19142223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19142223 | http://www.w3.org/2000/01/rdf-schema#comment | "DTNBP1 has been recognized as a schizophrenia susceptible gene, and its protein product, dysbindin-1, is down-regulated in the brains of schizophrenic patients. However, little is known about the physiological role of dysbindin-1 in the central nervous system. We hypothesized that disruption of dysbindin-1 with unidentified proteins could contribute to pathogenesis and the symptoms of schizophrenia. GST pull-down from human neuroblastoma lysates showed an association of dysbindin-1 with the DNA-dependent protein kinase (DNA-PK) complex. The DNA-PK complex interacts only with splice isoforms A and B, but not with C. We found that isoforms A and B localized in nucleus, where the kinase complex exist, whereas the isoform C was found exclusively in cytosol. Furthermore, results of phosphorylation assay suggest that the DNA-PK complex phosphorylated dysbindin-1 isoforms A and B in cells. These observations suggest that DNA-PK regulates the dysbindin-1 isoforms A and B by phosphorylation in nucleus. Isoform C does not contain exons from 1 to 6. Since schizophrenia-related single nucleotide polymorphisms (SNPs) occur in these introns between exon 1 and exon 6, we suggest that these SNPs might affect splicing of DTNBP1, which leads to impairment of the functional interaction between dysbindin-1 and DNA-PK in schizophrenic patients."xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0004199"xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0004199"xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/author | "Oyama S."xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/author | "Oyama S."xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/author | "Ishiura S."xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/author | "Ishiura S."xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/author | "Yamakawa H."xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/author | "Yamakawa H."xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/author | "Sasagawa N."xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/author | "Sasagawa N."xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/author | "Futai E."xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/author | "Futai E."xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/author | "Hosoi Y."xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/author | "Hosoi Y."xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/pages | "E4199"xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/pages | "E4199"xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/title | "Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA-dependent protein kinase complex in an isoform-dependent manner."xsd:string |
| http://purl.uniprot.org/citations/19142223 | http://purl.uniprot.org/core/title | "Dysbindin-1, a schizophrenia-related protein, functionally interacts with the DNA-dependent protein kinase complex in an isoform-dependent manner."xsd:string |