| http://purl.uniprot.org/citations/19203579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19203579 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19203579 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA double-strand breaks (DSBs) not only interrupt the genetic information, but also disrupt the chromatin structure, and both impairments require repair mechanisms to ensure genome integrity. We showed previously that RNF8-mediated chromatin ubiquitylation protects genome integrity by promoting the accumulation of repair factors at DSBs. Here, we provide evidence that, while RNF8 is necessary to trigger the DSB-associated ubiquitylations, it is not sufficient to sustain conjugated ubiquitin in this compartment. We identified RNF168 as a novel chromatin-associated ubiquitin ligase with an ability to bind ubiquitin. We show that RNF168 interacts with ubiquitylated H2A, assembles at DSBs in an RNF8-dependent manner, and, by targeting H2A and H2AX, amplifies local concentration of lysine 63-linked ubiquitin conjugates to the threshold required for retention of 53BP1 and BRCA1. Thus, RNF168 defines a new pathway involving sequential ubiquitylations on damaged chromosomes and uncovers a functional cooperation between E3 ligases in genome maintenance."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2008.12.041"xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2008.12.041"xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Durocher D."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Durocher D."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Lukas C."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Lukas C."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Pepperkok R."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Pepperkok R."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Ellenberg J."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Ellenberg J."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Lukas J."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Lukas J."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Panier S."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Panier S."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Bartek J."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Bartek J."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Bekker-Jensen S."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Bekker-Jensen S."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Mailand N."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Mailand N."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Menard P."xsd:string |
| http://purl.uniprot.org/citations/19203579 | http://purl.uniprot.org/core/author | "Menard P."xsd:string |