| http://purl.uniprot.org/citations/19228876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19228876 | http://www.w3.org/2000/01/rdf-schema#comment | "A role for c-Abl in B cell development and signaling has been suggested by previous work showing that c-Abl-deficient mice have defects in bone marrow B cell development and that c-Abl-deficient B cells are hypoproliferative in response to antigen receptor stimulation. Here we show that in addition to defects in early B cell development, c-Abl-deficient mice have defects in peripheral B cell development, including reduced percentages of peritoneal B-1 cells as well as transitional and marginal zone B cells in the spleen. It has been shown that c-Abl kinase activity increases upon B cell receptor (BCR) stimulation and that one of the targets of tyrosine phosphorylation by c-Abl is CD19. However, the consequences of c-Abl activity on B cell activation and CD19 signaling remain unknown. Here, we show that c-Abl-deficient splenic B cells exhibit reduced calcium flux in response to CD19 cross-linking, consistent with a role for c-Abl in CD19-dependent signaling. Additionally, we show that c-Abl-deficient B cells are defective in their ability to be activated in response to antigen receptor engagement, suggesting a functional role for c-Abl in BCR-dependent activation signaling pathways."xsd:string |
| http://purl.uniprot.org/citations/19228876 | http://purl.org/dc/terms/identifier | "doi:10.1093/intimm/dxp006"xsd:string |
| http://purl.uniprot.org/citations/19228876 | http://purl.uniprot.org/core/author | "Goff S.P."xsd:string |
| http://purl.uniprot.org/citations/19228876 | http://purl.uniprot.org/core/author | "Liberatore R.A."xsd:string |
| http://purl.uniprot.org/citations/19228876 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19228876 | http://purl.uniprot.org/core/name | "Int Immunol"xsd:string |
| http://purl.uniprot.org/citations/19228876 | http://purl.uniprot.org/core/pages | "403-414"xsd:string |
| http://purl.uniprot.org/citations/19228876 | http://purl.uniprot.org/core/title | "c-Abl-deficient mice exhibit reduced numbers of peritoneal B-1 cells and defects in BCR-induced B cell activation."xsd:string |
| http://purl.uniprot.org/citations/19228876 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/19228876 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19228876 |
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| http://purl.uniprot.org/uniprot/P00520#attribution-A942CA9DC46E1AF3B66190F2CBFA7253 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19228876 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVY6-mappedCitation-19228876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19228876 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXS9-mappedCitation-19228876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19228876 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY65-mappedCitation-19228876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19228876 |
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| http://purl.uniprot.org/uniprot/#_P00520-mappedCitation-19228876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19228876 |
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| http://purl.uniprot.org/uniprot/#_P25918-mappedCitation-19228876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19228876 |
| http://purl.uniprot.org/uniprot/#_Q3TQG5-mappedCitation-19228876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19228876 |
| http://purl.uniprot.org/uniprot/#_Q3TA95-mappedCitation-19228876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19228876 |
| http://purl.uniprot.org/uniprot/#_Q3TM13-mappedCitation-19228876 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19228876 |