| http://purl.uniprot.org/citations/19229036 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19229036 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19229036 | http://www.w3.org/2000/01/rdf-schema#comment | "Heat shock factor 1 (HSF1) is essential for protecting cells from protein-damaging stress associated with misfolded proteins and regulates the insulin-signaling pathway and aging. Here, we show that human HSF1 is inducibly acetylated at a critical residue that negatively regulates DNA binding activity. Activation of the deacetylase and longevity factor SIRT1 prolonged HSF1 binding to the heat shock promoter Hsp70 by maintaining HSF1 in a deacetylated, DNA-binding competent state. Conversely, down-regulation of SIRT1 accelerated the attenuation of the heat shock response (HSR) and release of HSF1 from its cognate promoter elements. These results provide a mechanistic basis for the requirement of HSF1 in the regulation of life span and establish a role for SIRT1 in protein homeostasis and the HSR."xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1165946"xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1165946"xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/author | "Stevens S.M. Jr."xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/author | "Stevens S.M. Jr."xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/author | "Morimoto R.I."xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/author | "Morimoto R.I."xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/author | "Westerheide S.D."xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/author | "Westerheide S.D."xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/author | "Sistonen L."xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/author | "Sistonen L."xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/author | "Anckar J."xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/author | "Anckar J."xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/pages | "1063-1066"xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/pages | "1063-1066"xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/title | "Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1."xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/title | "Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1."xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/volume | "323"xsd:string |
| http://purl.uniprot.org/citations/19229036 | http://purl.uniprot.org/core/volume | "323"xsd:string |