| http://purl.uniprot.org/citations/19234109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19234109 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA damage response (DDR) acts as a tumorigenesis barrier, and any defects in the DDR machinery may lead to cancer. SOX4 expression is elevated in many types of tumors; however, its role in DDR is still largely unknown. Here, we show that SOX4, a new DNA damage sensor, is required for the activation of p53 tumor suppressor in response to DNA damage. Notably, SOX4 interacts with and stabilizes p53 protein by blocking Mdm2-mediated p53 ubiquitination and degradation. Furthermore, SOX4 enhances p53 acetylation by interacting with p300/CBP and facilitating p300/CBP/p53 complex formation. In concert with these results, SOX4 promotes cell cycle arrest and apoptosis, and it inhibits tumorigenesis in a p53-dependent manner. Therefore, these findings highlight SOX4 as a potential key factor in regulating DDR-associated cancer."xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0810147106"xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://purl.uniprot.org/core/author | "Pan X."xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://purl.uniprot.org/core/author | "Zhao J."xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://purl.uniprot.org/core/author | "Yu M."xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://purl.uniprot.org/core/author | "Li H.Y."xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://purl.uniprot.org/core/author | "Zhang H.Y."xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://purl.uniprot.org/core/author | "Zhou T."xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://purl.uniprot.org/core/author | "Mu R."xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://purl.uniprot.org/core/author | "Zhang X.M."xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://purl.uniprot.org/core/author | "Li A.L."xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://purl.uniprot.org/core/author | "Man J.H."xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://purl.uniprot.org/core/author | "Zhang W.N."xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://purl.uniprot.org/core/author | "Gong W.L."xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://purl.uniprot.org/core/author | "Zhang P.J."xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19234109 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://purl.uniprot.org/core/pages | "3788-3793"xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://purl.uniprot.org/core/title | "Induction of SOX4 by DNA damage is critical for p53 stabilization and function."xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19234109 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19234109 |
| http://purl.uniprot.org/citations/19234109 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19234109 |
| http://purl.uniprot.org/uniprot/P04637#attribution-80A5D8C43A40D3B82DB9456E73399CAF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19234109 |
| http://purl.uniprot.org/uniprot/Q06945#attribution-80A5D8C43A40D3B82DB9456E73399CAF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19234109 |