| http://purl.uniprot.org/citations/19243221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19243221 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19243221 | http://www.w3.org/2000/01/rdf-schema#comment | "The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Here we report that neuropilin tolloid-like 1 (Neto1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density. Neto1-null mice have depressed long-term potentiation (LTP) at Schaffer collateral-CA1 synapses, with the subunit dependency of LTP induction switching from the normal predominance of NR2A-to NR2B-NMDARs. NMDAR-dependent spatial learning and memory is depressed in Neto1-null mice, indicating that Neto1 regulates NMDA receptor-dependent synaptic plasticity and cognition. Remarkably, we also found that the deficits in LTP, learning, and memory in Neto1-null mice were rescued by the ampakine CX546 at doses without effect in wild-type. Together, our results establish the principle that auxiliary proteins are required for the normal abundance of NMDAR subunits at synapses, and demonstrate that an inherited learning defect can be rescued pharmacologically, a finding with therapeutic implications for humans."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.1000041"xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.1000041"xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "McInnes R.R."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "McInnes R.R."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "Ng D."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "Ng D."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "Szilard R.K."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "Szilard R.K."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "Pitcher G.M."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "Pitcher G.M."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "Salter M.W."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "Salter M.W."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "Roder J.C."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "Roder J.C."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "Joo D."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "Joo D."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "Clapcote S.J."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "Clapcote S.J."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "Cortez M."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "Cortez M."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "Kalia L.V."xsd:string |
| http://purl.uniprot.org/citations/19243221 | http://purl.uniprot.org/core/author | "Kalia L.V."xsd:string |