| http://purl.uniprot.org/citations/19278655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19278655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19278655 | http://www.w3.org/2000/01/rdf-schema#comment | "The human Hrs and STAM proteins comprise the ESCRT-0 complex, which sorts ubiquitinated cell surface receptors to lysosomes for degradation. Here we report a model for the complete ESCRT-0 complex based on the crystal structure of the Hrs-STAM core complex, previously solved domain structures, hydrodynamic measurements, and Monte Carlo simulations. ESCRT-0 expressed in insect cells has a hydrodynamic radius of RH = 7.9 nm and is a 1:1 heterodimer. The 2.3 Angstroms crystal structure of the ESCRT-0 core complex reveals two domain-swapped GAT domains and an antiparallel two-stranded coiled-coil, similar to yeast ESCRT-0. ESCRT-0 typifies a class of biomolecular assemblies that combine structured and unstructured elements, and have dynamic and open conformations to ensure versatility in target recognition. Coarse-grained Monte Carlo simulations constrained by experimental RH values for ESCRT-0 reveal a dynamic ensemble of conformations well suited for diverse functions."xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2009.01.012"xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2009.01.012"xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/author | "Ghirlando R."xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/author | "Ghirlando R."xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/author | "Ren X."xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/author | "Ren X."xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/author | "Hurley J.H."xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/author | "Hurley J.H."xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/author | "Kloer D.P."xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/author | "Kloer D.P."xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/author | "Kim Y.C."xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/author | "Kim Y.C."xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/author | "Hummer G."xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/author | "Hummer G."xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/author | "Saidi L.F."xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/author | "Saidi L.F."xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/pages | "406-416"xsd:string |
| http://purl.uniprot.org/citations/19278655 | http://purl.uniprot.org/core/pages | "406-416"xsd:string |