| http://purl.uniprot.org/citations/19282290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19282290 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19282290 | http://www.w3.org/2000/01/rdf-schema#comment | "Almost every protein-coding gene undergoes pre-mRNA splicing, and the majority of these pre-mRNAs are alternatively spliced. Alternative exon usage is regulated by the transient formation of protein complexes on the pre-mRNA that typically contain heterogeneous nuclear ribonucleoproteins (hnRNPs). Here we characterize hnRNP G, a member of the hnRNP class of proteins. We show that hnRNP G is a nuclear protein that is expressed in different concentrations in various tissues and that interacts with other splicing regulatory proteins. hnRNP G is part of the supraspliceosome, where it regulates alternative splice site selection in a concentration-dependent manner. Its action on alternative exons can occur without a functional RNA-recognition motif by binding to other splicing regulatory proteins. The RNA-recognition motif of hnRNP G binds to a loose consensus sequence containing a CC(A/C) motif, and hnRNP G preferentially regulates alternative exons where this motif is clustered in close proximity. The X-chromosomally encoded hnRNP G regulates different RNAs than its Y-chromosomal paralogue RNA-binding motif protein, Y-linked (RBMY), suggesting that differences in alternative splicing, evoked by the sex-specific expression of hnRNP G and RBMY, could contribute to molecular sex differences in mammals."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m901026200"xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m901026200"xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Soreq H."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Soreq H."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Stamm S."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Stamm S."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Hiller M."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Hiller M."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Ben-Ari S."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Ben-Ari S."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Benderska N."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Benderska N."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Bracco L."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Bracco L."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Elliott D."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Elliott D."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Hartmann A.M."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Hartmann A.M."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Heinrich B."xsd:string |
| http://purl.uniprot.org/citations/19282290 | http://purl.uniprot.org/core/author | "Heinrich B."xsd:string |