| http://purl.uniprot.org/citations/19291698 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19291698 | http://www.w3.org/2000/01/rdf-schema#comment | "iNOS plays an important role in mediating inflammation. In this study, we found that iNOS-derived NO was increased 2.4-fold in the serum samples of 101 patients infected with influenza A virus in comparison with samples of 105 healthy individuals. In A549 human lung epithelial cells, infection with influenza A virus or stimulation with poly(I:C)+IFN-gamma resulted in increased mRNA and protein levels of both IL-32 and iNOS, with subsequent release of NO. Over-expression of IL-32 resulted in upregulated iNOS expression with subsequent NO production. Knock down of IL-32 by IL-32-specific siRNA resulted in the inhibition of dsRNA-induced expression of iNOS and NO release, indicating that IL-32 is an upstream regulatory factor of dsRNA-triggered iNOS production. Surprisingly, over-expression of iNOS resulted in the reduction of IL-32 expression, and suppression of iNOS by the selective iNOS inhibitor S-methylisothiourea sulfate stimulated IL-32 expression, indicating that a negative feedback mechanism operates between the iNOS/NO and IL-32 systems. These findings suggest that influenza A virus infection activates IL-32 and iNOS expression by a heretofore unrecognized complex mechanism, in which the two pro-inflammatory factors regulate each other, involving positive and negative feedback regulatory loops."xsd:string |
| http://purl.uniprot.org/citations/19291698 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200838885"xsd:string |
| http://purl.uniprot.org/citations/19291698 | http://purl.uniprot.org/core/author | "Feng Y."xsd:string |
| http://purl.uniprot.org/citations/19291698 | http://purl.uniprot.org/core/author | "Hu P."xsd:string |
| http://purl.uniprot.org/citations/19291698 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/19291698 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/19291698 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/19291698 | http://purl.uniprot.org/core/author | "Hao Q."xsd:string |
| http://purl.uniprot.org/citations/19291698 | http://purl.uniprot.org/core/author | "Sun W."xsd:string |
| http://purl.uniprot.org/citations/19291698 | http://purl.uniprot.org/core/author | "Kang L."xsd:string |
| http://purl.uniprot.org/citations/19291698 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/19291698 | http://purl.uniprot.org/core/author | "Yang F."xsd:string |
| http://purl.uniprot.org/citations/19291698 | http://purl.uniprot.org/core/author | "Zhu Y."xsd:string |
| http://purl.uniprot.org/citations/19291698 | http://purl.uniprot.org/core/author | "Gong R."xsd:string |
| http://purl.uniprot.org/citations/19291698 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19291698 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19291698 | http://purl.uniprot.org/core/pages | "1019-1024"xsd:string |
| http://purl.uniprot.org/citations/19291698 | http://purl.uniprot.org/core/title | "Negative feedback regulation of IL-32 production by iNOS activation in response to dsRNA or influenza virus infection."xsd:string |
| http://purl.uniprot.org/citations/19291698 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/19291698 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19291698 |
| http://purl.uniprot.org/citations/19291698 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19291698 |
| http://purl.uniprot.org/uniprot/#_C6GKH1-mappedCitation-19291698 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19291698 |
| http://purl.uniprot.org/uniprot/#_C6GKH2-mappedCitation-19291698 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19291698 |
| http://purl.uniprot.org/uniprot/#_G3LU47-mappedCitation-19291698 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19291698 |