| http://purl.uniprot.org/citations/19302042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19302042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19302042 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in the transcriptional regulator, Aire, cause APECED, a polyglandular autoimmune disease with monogenic transmission. Animal models of APECED have revealed that Aire plays an important role in T cell tolerance induction in the thymus, mainly by promoting ectopic expression of a large repertoire of transcripts encoding proteins normally restricted to differentiated organs residing in the periphery. The absence of Aire results in impaired clonal deletion of self-reactive thymocytes, which escape into the periphery and attack a variety of organs. In addition, Aire is a proapoptotic factor, expressed at the final maturation stage of thymic medullary epithelial cells, a function that may promote cross-presentation of the antigens encoded by Aire-induced transcripts in these cells. Transcriptional regulation by Aire is unusual in being very broad, context-dependent, probabilistic, and noisy. Structure/function analyses and identification of its interaction partners suggest that Aire may impact transcription at several levels, including nucleosome displacement during elongation and transcript splicing or other aspects of maturation."xsd:string |
| http://purl.uniprot.org/citations/19302042 | http://purl.org/dc/terms/identifier | "doi:10.1146/annurev.immunol.25.022106.141532"xsd:string |
| http://purl.uniprot.org/citations/19302042 | http://purl.org/dc/terms/identifier | "doi:10.1146/annurev.immunol.25.022106.141532"xsd:string |
| http://purl.uniprot.org/citations/19302042 | http://purl.uniprot.org/core/author | "Benoist C."xsd:string |
| http://purl.uniprot.org/citations/19302042 | http://purl.uniprot.org/core/author | "Benoist C."xsd:string |
| http://purl.uniprot.org/citations/19302042 | http://purl.uniprot.org/core/author | "Mathis D."xsd:string |
| http://purl.uniprot.org/citations/19302042 | http://purl.uniprot.org/core/author | "Mathis D."xsd:string |
| http://purl.uniprot.org/citations/19302042 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19302042 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19302042 | http://purl.uniprot.org/core/name | "Annu. Rev. Immunol."xsd:string |
| http://purl.uniprot.org/citations/19302042 | http://purl.uniprot.org/core/name | "Annu. Rev. Immunol."xsd:string |
| http://purl.uniprot.org/citations/19302042 | http://purl.uniprot.org/core/pages | "287-312"xsd:string |
| http://purl.uniprot.org/citations/19302042 | http://purl.uniprot.org/core/pages | "287-312"xsd:string |
| http://purl.uniprot.org/citations/19302042 | http://purl.uniprot.org/core/title | "Aire."xsd:string |
| http://purl.uniprot.org/citations/19302042 | http://purl.uniprot.org/core/title | "Aire."xsd:string |
| http://purl.uniprot.org/citations/19302042 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/19302042 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/19302042 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19302042 |
| http://purl.uniprot.org/citations/19302042 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19302042 |
| http://purl.uniprot.org/citations/19302042 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19302042 |
| http://purl.uniprot.org/citations/19302042 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19302042 |
| http://purl.uniprot.org/uniprot/Q9Z0E3 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/19302042 |
| http://purl.uniprot.org/uniprot/O43918 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/19302042 |