| http://purl.uniprot.org/citations/19339211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19339211 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19339211 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia-inducible factor-1 (HIF-1) is a major transcription factor regulating the response of tumor cells to hypoxia and is comprised of HIF-1alpha and Arnt (HIF-1beta). In mammalian cells, HIF-1 protein levels are regulated by three HIF-prolyl hydroxylases, termed PHD1, PHD2 and PHD3. To assess whether intracellular localization of PHD1 and PHD2 affects the hypoxic response via HIF-1, we investigated the localization signal of PHDs. PHD1 possessed at least one nuclear localization signal (NLS), and PHD2 contained a region as essential for nuclear export in their N-terminal region. Treatment of cells with leptomycin B revealed that PHD2 was able to shuttle between the cytoplasm and the nucleus. Reporter assay indicated that differences in the intracellular distribution of PHD1 did not influence on HIF-1alpha activity. However, a PHD2 mutant lacking the region for nuclear export exhibited significantly reduced effect to HIF-1alpha activity compared to wild-type PHD2, suggesting that the regulation of the intracellular distribution of PHD2 is an effective pathway for the control of the hypoxic response."xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2009.01.014"xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2009.01.014"xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/author | "Yoshida A."xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/author | "Yoshida A."xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/author | "Yasumoto K."xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/author | "Yasumoto K."xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/author | "Torii S."xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/author | "Torii S."xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/author | "Sogawa K."xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/author | "Sogawa K."xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/author | "Kowata Y."xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/author | "Kowata Y."xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/name | "Biochim. Biophys. Acta"xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/name | "Biochim. Biophys. Acta"xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/pages | "792-797"xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/pages | "792-797"xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/title | "Role of the intracellular localization of HIF-prolyl hydroxylases."xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/title | "Role of the intracellular localization of HIF-prolyl hydroxylases."xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/volume | "1793"xsd:string |
| http://purl.uniprot.org/citations/19339211 | http://purl.uniprot.org/core/volume | "1793"xsd:string |