| http://purl.uniprot.org/citations/19372391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19372391 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19372391 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA cytosine methylation is crucial for retrotransposon silencing and mammalian development. In a computational search for enzymes that could modify 5-methylcytosine (5mC), we identified TET proteins as mammalian homologs of the trypanosome proteins JBP1 and JBP2, which have been proposed to oxidize the 5-methyl group of thymine. We show here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro. hmC is present in the genome of mouse embryonic stem cells, and hmC levels decrease upon RNA interference-mediated depletion of TET1. Thus, TET proteins have potential roles in epigenetic regulation through modification of 5mC to hmC."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1170116"xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1170116"xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Aravind L."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Aravind L."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Iyer L.M."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Iyer L.M."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Agarwal S."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Agarwal S."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Liu D.R."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Liu D.R."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Rao A."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Rao A."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Pastor W.A."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Pastor W.A."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Tahiliani M."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Tahiliani M."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Bandukwala H."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Bandukwala H."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Brudno Y."xsd:string |
| http://purl.uniprot.org/citations/19372391 | http://purl.uniprot.org/core/author | "Brudno Y."xsd:string |