| http://purl.uniprot.org/citations/19450559 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19450559 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor STAT1 plays a role in promoting apoptotic cell death, whereas the related STAT3 transcription factor protects cardiac myocytes from ischemia/reperfusion (I/R) injury or oxidative stress. Cytokines belonging to the IL-6 family activate the JAK-STAT3 pathway, but also activate other cytoprotective pathways such as the MAPK-ERK or the PI3-AKT pathway. It is therefore unclear whether STAT3 is the only cytoprotective mediator against oxidative stress-induced cell death. Overexpression of STAT3 in primary neonatal rat ventricular myocytes (NRVM) protects against I/R-induced cell death. Moreover, a dominant negative STAT3 adenovirus (Ad ST3-DN) enhanced apoptotic cell death (81.2+/-6.9%) compared to control infected NRVM (46.0+/-3.1%) following I/R. Depletion of STAT3 sensitized cells to apoptotic cell death following oxidative stress. These results provide direct evidence for the role of STAT3 as a cytoprotective transcription factor in cells exposed to oxidative stress."xsd:string |
| http://purl.uniprot.org/citations/19450559 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2009.05.051"xsd:string |
| http://purl.uniprot.org/citations/19450559 | http://purl.uniprot.org/core/author | "McCormick J."xsd:string |
| http://purl.uniprot.org/citations/19450559 | http://purl.uniprot.org/core/author | "Latchman D.S."xsd:string |
| http://purl.uniprot.org/citations/19450559 | http://purl.uniprot.org/core/author | "Knight R.A."xsd:string |
| http://purl.uniprot.org/citations/19450559 | http://purl.uniprot.org/core/author | "Barry S.P."xsd:string |
| http://purl.uniprot.org/citations/19450559 | http://purl.uniprot.org/core/author | "Stephanou A."xsd:string |
| http://purl.uniprot.org/citations/19450559 | http://purl.uniprot.org/core/author | "Townsend P.A."xsd:string |
| http://purl.uniprot.org/citations/19450559 | http://purl.uniprot.org/core/author | "Scarabelli T.M."xsd:string |
| http://purl.uniprot.org/citations/19450559 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19450559 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/19450559 | http://purl.uniprot.org/core/pages | "324-329"xsd:string |
| http://purl.uniprot.org/citations/19450559 | http://purl.uniprot.org/core/title | "STAT3 deletion sensitizes cells to oxidative stress."xsd:string |
| http://purl.uniprot.org/citations/19450559 | http://purl.uniprot.org/core/volume | "385"xsd:string |
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