http://purl.uniprot.org/citations/19464326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/19464326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/19464326 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundThe HSPB family is one of the more diverse families within the group of HSP families. Some members have chaperone-like activities and/or play a role in cytoskeletal stabilization. Some members also show a dynamic, stress-induced translocation to SC35 splicing speckles. If and how these features are interrelated and if they are shared by all members are yet unknown.MethodsTissue expression data and interaction and co-regulated gene expression data of the human HSPB members was analyzed using bioinformatics. Using a gene expression library, sub-cellular distribution of the diverse members was analyzed by confocal microscopy. Chaperone activity was measured using a cellular luciferase refolding assay.ResultsOnline databases did not accurately predict the sub-cellular distribution of all the HSPB members. A novel and non-predicted finding was that HSPB7 constitutively localized to SC35 splicing speckles, driven by its N-terminus. Unlike HSPB1 and HSPB5, that chaperoned heat unfolded substrates and kept them folding competent, HSPB7 did not support refolding.ConclusionOur data suggest a non-chaperone-like role of HSPB7 at SC35 speckles.General significanceThe functional divergence between HSPB members seems larger than previously expected and also includes non-canonical members lacking classical chaperone-like functions."xsd:string |
http://purl.uniprot.org/citations/19464326 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2009.05.005"xsd:string |
http://purl.uniprot.org/citations/19464326 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2009.05.005"xsd:string |
http://purl.uniprot.org/citations/19464326 | http://purl.uniprot.org/core/author | "Kampinga H.H."xsd:string |
http://purl.uniprot.org/citations/19464326 | http://purl.uniprot.org/core/author | "Kampinga H.H."xsd:string |
http://purl.uniprot.org/citations/19464326 | http://purl.uniprot.org/core/author | "Kanon B."xsd:string |
http://purl.uniprot.org/citations/19464326 | http://purl.uniprot.org/core/author | "Kanon B."xsd:string |
http://purl.uniprot.org/citations/19464326 | http://purl.uniprot.org/core/author | "Vos M.J."xsd:string |
http://purl.uniprot.org/citations/19464326 | http://purl.uniprot.org/core/author | "Vos M.J."xsd:string |
http://purl.uniprot.org/citations/19464326 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
http://purl.uniprot.org/citations/19464326 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
http://purl.uniprot.org/citations/19464326 | http://purl.uniprot.org/core/name | "Biochim. Biophys. Acta"xsd:string |
http://purl.uniprot.org/citations/19464326 | http://purl.uniprot.org/core/name | "Biochim. Biophys. Acta"xsd:string |
http://purl.uniprot.org/citations/19464326 | http://purl.uniprot.org/core/pages | "1343-1353"xsd:string |
http://purl.uniprot.org/citations/19464326 | http://purl.uniprot.org/core/pages | "1343-1353"xsd:string |
http://purl.uniprot.org/citations/19464326 | http://purl.uniprot.org/core/title | "HSPB7 is a SC35 speckle resident small heat shock protein."xsd:string |
http://purl.uniprot.org/citations/19464326 | http://purl.uniprot.org/core/title | "HSPB7 is a SC35 speckle resident small heat shock protein."xsd:string |
http://purl.uniprot.org/citations/19464326 | http://purl.uniprot.org/core/volume | "1793"xsd:string |
http://purl.uniprot.org/citations/19464326 | http://purl.uniprot.org/core/volume | "1793"xsd:string |
http://purl.uniprot.org/citations/19464326 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19464326 |
http://purl.uniprot.org/citations/19464326 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19464326 |
http://purl.uniprot.org/citations/19464326 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19464326 |
http://purl.uniprot.org/citations/19464326 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19464326 |