| http://purl.uniprot.org/citations/19465938 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19465938 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19465938 | http://www.w3.org/2000/01/rdf-schema#comment | "The WWOX gene encodes a candidate tumor suppressor protein (WWOX) implicated in a variety of human diseases such as cancer. To better understand the molecular mechanisms of WWOX action, we investigated novel partners of this protein. Using the two-hybrid system and a coimmunoprecipitation assay, we observed a physical association between WWOX and the Dishevelled protein (Dvl) family signaling elements involved in the Wnt/beta-catenin pathway. We found that enforced WWOX expression inhibited, and inhibition of endogenous WWOX expression stimulated the transcriptional activity of the Wnt/beta-catenin pathway. Inhibition of endogenous WWOX expression also enhanced the effect of Wnt-3a on beta-catenin stability. Moreover, we observed the sequestration of Dvl-2 wild type and Dvl-2NESm, a mutated form of Dvl-2 predominantly localized in the nucleus, in the cytoplasm compartment by WWOX. Our results indicate that WWOX is a novel inhibitor of the Wnt/beta-catenin pathway. WWOX would act, at least in part, by preventing the nuclear import of the Dvl proteins."xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2009.120"xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2009.120"xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/author | "Camonis J."xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/author | "Camonis J."xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/author | "Formstecher E."xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/author | "Formstecher E."xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/author | "Lidereau R."xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/author | "Lidereau R."xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/author | "Driouch K."xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/author | "Driouch K."xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/author | "Bouteille N."xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/author | "Bouteille N."xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/author | "Lallemand F."xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/author | "Lallemand F."xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/author | "Hage P.E."xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/author | "Hage P.E."xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/author | "Sin S."xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/author | "Sin S."xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/19465938 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |