| http://purl.uniprot.org/citations/19478884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19478884 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19478884 | http://www.w3.org/2000/01/rdf-schema#comment | "Cdc7p-Dbf4p is a conserved protein kinase required for the initiation of DNA replication. The Dbf4p regulatory subunit binds Cdc7p and is essential for Cdc7p kinase activation, however, the N-terminal third of Dbf4p is dispensable for its essential replication activities. Here, we define a short N-terminal Dbf4p region that targets Cdc7p-Dbf4p kinase to Cdc5p, the single Polo kinase in budding yeast that regulates mitotic progression and cytokinesis. Dbf4p mediates an interaction with the Polo substrate-binding domain to inhibit its essential role during mitosis. Although Dbf4p does not inhibit Polo kinase activity, it nonetheless inhibits Polo-mediated activation of the mitotic exit network (MEN), presumably by altering Polo substrate targeting. In addition, although dbf4 mutants defective for interaction with Polo transit S-phase normally, they aberrantly segregate chromosomes following nuclear misorientation. Therefore, Cdc7p-Dbf4p prevents inappropriate exit from mitosis by inhibiting Polo kinase and functions in the spindle position checkpoint."xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1000498"xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1000498"xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://purl.uniprot.org/core/author | "Chen Y.-C."xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://purl.uniprot.org/core/author | "Chen Y.-C."xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://purl.uniprot.org/core/author | "Weinreich M."xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://purl.uniprot.org/core/author | "Weinreich M."xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://purl.uniprot.org/core/author | "Gabrielse C."xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://purl.uniprot.org/core/author | "Gabrielse C."xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://purl.uniprot.org/core/author | "Miller C.T."xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://purl.uniprot.org/core/author | "Miller C.T."xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19478884 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19478884 | http://purl.uniprot.org/core/name | "PLoS Genet."xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://purl.uniprot.org/core/name | "PLoS Genet."xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://purl.uniprot.org/core/pages | "E1000498"xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://purl.uniprot.org/core/pages | "E1000498"xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://purl.uniprot.org/core/title | "Cdc7p-Dbf4p regulates mitotic exit by inhibiting Polo kinase."xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://purl.uniprot.org/core/title | "Cdc7p-Dbf4p regulates mitotic exit by inhibiting Polo kinase."xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/19478884 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19478884 |
| http://purl.uniprot.org/citations/19478884 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19478884 |