| http://purl.uniprot.org/citations/19535340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19535340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19535340 | http://www.w3.org/2000/01/rdf-schema#comment | "SIRT3 is a major mitochondrial NAD(+)-dependent protein deacetylase playing important roles in regulating mitochondrial metabolism and energy production and has been linked to the beneficial effects of exercise and caloric restriction. SIRT3 is emerging as a potential therapeutic target to treat metabolic and neurological diseases. We report the first sets of crystal structures of human SIRT3, an apo-structure with no substrate, a structure with a peptide containing acetyl lysine of its natural substrate acetyl-CoA synthetase 2, a reaction intermediate structure trapped by a thioacetyl peptide, and a structure with the dethioacetylated peptide bound. These structures provide insights into the conformational changes induced by the two substrates required for the reaction, the acetylated substrate peptide and NAD(+). In addition, the binding study by isothermal titration calorimetry suggests that the acetylated peptide is the first substrate to bind to SIRT3, before NAD(+). These structures and biophysical studies provide key insight into the structural and functional relationship of the SIRT3 deacetylation activity."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.014928"xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.014928"xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Jin L."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Jin L."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Mao C."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Mao C."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Wei W."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Wei W."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Peng H."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Peng H."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Westphal C.H."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Westphal C.H."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Cai J."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Cai J."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Dai H."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Dai H."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Bemis J.E."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Bemis J.E."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Choy W."xsd:string |
| http://purl.uniprot.org/citations/19535340 | http://purl.uniprot.org/core/author | "Choy W."xsd:string |