| http://purl.uniprot.org/citations/19540338 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19540338 | http://www.w3.org/2000/01/rdf-schema#comment | "JNK signaling functions to induce defense mechanisms that protect organisms against acute oxidative and xenobiotic insults. Using Drosophila as a model system, we investigated the role of autophagy as such a JNK-regulated protective mechanism. We show that oxidative stress can induce autophagy in the intestinal epithelium by a mechanism that requires JNK signaling. Consistently, artificial activation of JNK in the gut gives rise to an autophagy phenotype. JNK signaling can induce the expression of several autophagy-related (ATG) genes, and the integrity of these genes is required for the stress protective function of the JNK pathway. In contrast to autophagy induced by oxidative stress, non-stress related autophagy, as it occurs for example in starving adipose or intestinal tissue, or during metamorphosis, proceeds independently of JNK signaling. Autophagy thus emerges as a multifunctional process that organisms employ in a variety of different situations using separate regulatory mechanisms."xsd:string |
| http://purl.uniprot.org/citations/19540338 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mod.2009.06.1082"xsd:string |
| http://purl.uniprot.org/citations/19540338 | http://purl.uniprot.org/core/author | "Bohmann D."xsd:string |
| http://purl.uniprot.org/citations/19540338 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/19540338 | http://purl.uniprot.org/core/author | "Wang M.C."xsd:string |
| http://purl.uniprot.org/citations/19540338 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19540338 | http://purl.uniprot.org/core/name | "Mech Dev"xsd:string |
| http://purl.uniprot.org/citations/19540338 | http://purl.uniprot.org/core/pages | "624-637"xsd:string |
| http://purl.uniprot.org/citations/19540338 | http://purl.uniprot.org/core/title | "JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy."xsd:string |
| http://purl.uniprot.org/citations/19540338 | http://purl.uniprot.org/core/volume | "126"xsd:string |
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