| http://purl.uniprot.org/citations/19542454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19542454 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19542454 | http://www.w3.org/2000/01/rdf-schema#comment | "Protective T cell responses elicited along chronic human CMV (HCMV) infections are sometimes dominated by CD8 T cell clones bearing highly related or identical public TCR in unrelated individuals. To understand the principles that guide emergence of these public T cell responses, we have performed structural, biophysical, and functional analyses of an immunodominant public TCR (RA14) directed against a major HLA-A*0201-restricted HCMV Ag (pp65(495-503)) and selected in vivo from a diverse repertoire after chronic stimulations. Unlike the two immunodominant public TCRs crystallized so far, which focused on one peptide hotspot, the HCMV-specific RA14 TCR interacts with the full array of available peptide residues. The conservation of some peptide-MHC complex-contacting amino acids by lower-affinity TCRs suggests a shared TCR-peptide-MHC complex docking mode and supports an Ag-driven selection of optimal TCRs. Therefore, the emergence of a public TCR of an oligoclonal Ag-specific response after repeated viral stimulations is based on a receptor displaying a high structural complementarity with the entire peptide and focusing on three peptide hotspots. This highlights key parameters underlying the selection of a protective T cell response against HCMV infection, which remains a major health issue in patients undergoing bone marrow transplantation."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0900556"xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0900556"xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Housset D."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Housset D."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Chouquet A."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Chouquet A."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Gras S."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Gras S."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Bonneville M."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Bonneville M."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Debeaupuis E."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Debeaupuis E."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Echasserieau K."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Echasserieau K."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Le Gorrec M."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Le Gorrec M."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Saulquin X."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Saulquin X."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Thielens N."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Thielens N."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Malissen B."xsd:string |
| http://purl.uniprot.org/citations/19542454 | http://purl.uniprot.org/core/author | "Malissen B."xsd:string |