| http://purl.uniprot.org/citations/19543284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19543284 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19543284 | http://www.w3.org/2000/01/rdf-schema#comment | "Enterovirus 71 (EV71) is a major causative agent of hand, foot and mouth disease (HFMD), a common febrile disease occurring mainly in young children. Although clinical manifestations of HFMD are usually mild and self limiting, a severe EV71 outbreak can lead to a diverse array of neurological diseases. Identification of the specific cellular receptors is crucial for elucidating the mechanism of early virus-host interactions and the pathogenesis of enteroviruses. Here we identify human P-selectin glycoprotein ligand-1 (PSGL-1; CD162), a sialomucin membrane protein expressed on leukocytes that has a major role in early stages of inflammation, as a functional receptor for EV71 using an expression cloning method by panning. The N-terminal region of PSGL-1 binds specifically to EV71. Stable PSGL-1 expression allowed EV71 entry and replication, and development of cytopathic effects in nonsusceptible mouse L929 cells. Five out of eight EV71 strains bound soluble PSGL-1 and used intact PSGL-1 as the primary receptor for infection of Jurkat T cells. Three other EV71 strains did not use PSGL-1, suggesting the presence of strain-specific replication of EV71 in leukocytes. EV71 replicated in nonleukocyte cell lines in a PSGL-1-independent manner, indicating the presence of alternative receptor(s) for EV71. The identification of PSGL-1 as a receptor for EV71 sheds new light on a role for PSGL-1-positive leukocytes in cell tropism and pathogenesis during the course of HFMD and other EV71-mediated diseases."xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.1961"xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.1961"xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/author | "Nishimura Y."xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/author | "Nishimura Y."xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/author | "Miyamura T."xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/author | "Miyamura T."xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/author | "Shimojima M."xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/author | "Shimojima M."xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/author | "Shimizu H."xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/author | "Shimizu H."xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/author | "Wakita T."xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/author | "Wakita T."xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/author | "Tano Y."xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/author | "Tano Y."xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/name | "Nat. Med."xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/name | "Nat. Med."xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/pages | "794-797"xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/pages | "794-797"xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/title | "Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71."xsd:string |
| http://purl.uniprot.org/citations/19543284 | http://purl.uniprot.org/core/title | "Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71."xsd:string |