| http://purl.uniprot.org/citations/19543285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19543285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19543285 | http://www.w3.org/2000/01/rdf-schema#comment | "The use of fluorescently labeled major histocompatibility complex multimers has become an essential technique for analyzing disease- and therapy-induced T-cell immunity. Whereas classical major histocompatibility complex multimer analyses are well-suited for the detection of immune responses to a few epitopes, limitations on human-subject sample size preclude a comprehensive analysis of T-cell immunity. To address this issue, we developed a combinatorial encoding strategy that allows the parallel detection of a multitude of different T-cell populations in a single sample. Detection of T cells from peripheral blood by combinatorial encoding is as efficient as detection with conventionally labeled multimers but results in a substantially increased sensitivity and, most notably, allows comprehensive screens to be performed. We obtained proof of principle for the feasibility of large-scale screening of human material by analysis of human leukocyte antigen A3-restricted T-cell responses to known and potential melanoma-associated antigens in peripheral blood from individuals with melanoma."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.org/dc/terms/identifier | "doi:10.1038/nmeth.1345"xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.org/dc/terms/identifier | "doi:10.1038/nmeth.1345"xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Schumacher T.N."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Schumacher T.N."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Castermans E."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Castermans E."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Andersen R.S."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Andersen R.S."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Bakker A.H."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Bakker A.H."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Blank C."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Blank C."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Haanen J.B."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Haanen J.B."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Hadrup S.R."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Hadrup S.R."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Heemskerk M.H."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Heemskerk M.H."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Hombrink P."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Hombrink P."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Shu C.J."xsd:string |
| http://purl.uniprot.org/citations/19543285 | http://purl.uniprot.org/core/author | "Shu C.J."xsd:string |