| http://purl.uniprot.org/citations/19549681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19549681 | http://www.w3.org/2000/01/rdf-schema#comment | "The nascent phagosome progressively establishes an acidic milieu by acquiring a proton pump, the vacuolar-type ATPase (V-ATPase). However, the origin of phagosomal V-ATPase remains poorly understood. We found that phagosomes were enriched with the V-ATPase a3 subunit, which also accumulated in late endosomes and lysosomes. We modified the mouse Tcirg1 locus encoding subunit a3, to express an a3-GFP fusion protein. Live-cell imaging and immunofluorescence microscopy revealed that nascent phagosomes received the a3-GFP from tubular structures extending from lysosomes located in the perinuclear region. Macrophages from a3-deficient mice exhibited impaired acidification of phagosomes and delayed digestion of bacteria. These results show that lysosomal V-ATPase is recruited directly to the phagosomes via tubular lysosomes to establish the acidic environment hostile to pathogens."xsd:string |
| http://purl.uniprot.org/citations/19549681 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.050443"xsd:string |
| http://purl.uniprot.org/citations/19549681 | http://purl.uniprot.org/core/author | "Wada Y."xsd:string |
| http://purl.uniprot.org/citations/19549681 | http://purl.uniprot.org/core/author | "Aoyama M."xsd:string |
| http://purl.uniprot.org/citations/19549681 | http://purl.uniprot.org/core/author | "Kawamura N."xsd:string |
| http://purl.uniprot.org/citations/19549681 | http://purl.uniprot.org/core/author | "Tabata H."xsd:string |
| http://purl.uniprot.org/citations/19549681 | http://purl.uniprot.org/core/author | "Sun-Wada G.H."xsd:string |
| http://purl.uniprot.org/citations/19549681 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19549681 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/19549681 | http://purl.uniprot.org/core/pages | "2504-2513"xsd:string |
| http://purl.uniprot.org/citations/19549681 | http://purl.uniprot.org/core/title | "Direct recruitment of H+-ATPase from lysosomes for phagosomal acidification."xsd:string |
| http://purl.uniprot.org/citations/19549681 | http://purl.uniprot.org/core/volume | "122"xsd:string |
| http://purl.uniprot.org/citations/19549681 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19549681 |
| http://purl.uniprot.org/citations/19549681 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19549681 |
| http://purl.uniprot.org/uniprot/P17047#attribution-170197D10B710674514EA4B6B05AA4F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19549681 |
| http://purl.uniprot.org/uniprot/Q9CQD1#attribution-170197D10B710674514EA4B6B05AA4F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19549681 |
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| http://purl.uniprot.org/uniprot/O70439#attribution-170197D10B710674514EA4B6B05AA4F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19549681 |
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