| http://purl.uniprot.org/citations/19549784 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19549784 | http://www.w3.org/2000/01/rdf-schema#comment | "Ran-GTP interacts strongly with importin-beta, and this interaction promotes the release of the importin-alpha-nuclear localization signal cargo from importin-beta. Ran-GDP also interacts with importin-beta, but this interaction is 4 orders of magnitude weaker than the Ran-GTP.importin-beta interaction. Here we use the yeast complement of nuclear import proteins to show that the interaction between Ran-GDP and importin-beta promotes the dissociation of GDP from Ran. The release of GDP from the Ran-GDP-importin-beta complex stabilizes the complex, which cannot be dissociated by importin-alpha. Although Ran has a higher affinity for GDP compared with GTP, Ran in complex with importin-beta has a higher affinity for GTP. This feature is responsible for the generation of Ran-GTP from Ran-GDP by importin-beta. Ran-binding protein-1 (RanBP1) activates this reaction by forming a trimeric complex with Ran-GDP and importin-beta. Importin-alpha inhibits the GDP exchange reaction by sequestering importin-beta, whereas RanBP1 restores the GDP nucleotide exchange by importin-beta by forming a tetrameric complex with importin-beta, Ran, and importin-alpha. The exchange is also inhibited by nuclear-transport factor-2 (NTF2). We suggest a mechanism for nuclear import, additional to the established RCC1 (Ran-guanine exchange factor)-dependent pathway that incorporates these results."xsd:string |
| http://purl.uniprot.org/citations/19549784 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.019935"xsd:string |
| http://purl.uniprot.org/citations/19549784 | http://purl.uniprot.org/core/author | "Kobe B."xsd:string |
| http://purl.uniprot.org/citations/19549784 | http://purl.uniprot.org/core/author | "Robin G."xsd:string |
| http://purl.uniprot.org/citations/19549784 | http://purl.uniprot.org/core/author | "Carroll B.J."xsd:string |
| http://purl.uniprot.org/citations/19549784 | http://purl.uniprot.org/core/author | "Forwood J.K."xsd:string |
| http://purl.uniprot.org/citations/19549784 | http://purl.uniprot.org/core/author | "Marfori M."xsd:string |
| http://purl.uniprot.org/citations/19549784 | http://purl.uniprot.org/core/author | "Lonhienne T.G."xsd:string |
| http://purl.uniprot.org/citations/19549784 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19549784 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19549784 | http://purl.uniprot.org/core/pages | "22549-22558"xsd:string |
| http://purl.uniprot.org/citations/19549784 | http://purl.uniprot.org/core/title | "Importin-beta is a GDP-to-GTP exchange factor of Ran: implications for the mechanism of nuclear import."xsd:string |
| http://purl.uniprot.org/citations/19549784 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19549784 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19549784 |
| http://purl.uniprot.org/citations/19549784 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19549784 |
| http://purl.uniprot.org/uniprot/Q06142#attribution-89AD048C27DEE978EB1797E287D532DF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19549784 |
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