| http://purl.uniprot.org/citations/19559631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19559631 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19559631 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-33 (IL-33) is a member of the IL-1 family and is involved in polarization of T cells toward a T helper 2 (Th2) cell phenotype. IL-33 is thought to be activated via caspase-1-dependent proteolysis, similar to the proinflammatory cytokines IL-1 beta and IL-18, but this remains unproven. Here we showed that IL-33 was processed by caspases activated during apoptosis (caspase-3 and -7) but was not a physiological substrate for caspases associated with inflammation (caspase-1, -4, and -5). Furthermore, caspase-dependent processing of IL-33 was not required for ST2 receptor binding or ST2-dependent activation of the NF-kappaB transcription factor. Indeed, caspase-dependent proteolysis of IL-33 dramatically attenuated IL-33 bioactivity in vitro and in vivo. These data suggest that IL-33 does not require proteolysis for activation, but rather, that IL-33 bioactivity is diminished through caspase-dependent proteolysis within apoptotic cells. Thus, caspase-mediated proteolysis acts as a switch to dampen the proinflammatory properties of IL-33."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2009.05.007"xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2009.05.007"xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Brumatti G."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Brumatti G."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Martin S.J."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Martin S.J."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Taylor R.C."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Taylor R.C."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Vandenabeele P."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Vandenabeele P."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Sheridan C."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Sheridan C."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Afonina I.S."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Afonina I.S."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Kersse K."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Kersse K."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Cullen S.P."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Cullen S.P."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Duriez P.J."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Duriez P.J."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Lavelle E.C."xsd:string |
| http://purl.uniprot.org/citations/19559631 | http://purl.uniprot.org/core/author | "Lavelle E.C."xsd:string |