| http://purl.uniprot.org/citations/19576794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19576794 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19576794 | http://www.w3.org/2000/01/rdf-schema#comment | "Antiviral immunity is triggered by immunorecognition of viral nucleic acids. The cytosolic helicase RIG-I is a key sensor of viral infections and is activated by RNA containing a triphosphate at the 5' end. The exact structure of RNA activating RIG-I remains controversial. Here, we established a chemical approach for 5' triphosphate oligoribonucleotide synthesis and found that synthetic single-stranded 5' triphosphate oligoribonucleotides were unable to bind and activate RIG-I. Conversely, the addition of the synthetic complementary strand resulted in optimal binding and activation of RIG-I. Short double-strand conformation with base pairing of the nucleoside carrying the 5' triphosphate was required. RIG-I activation was impaired by a 3' overhang at the 5' triphosphate end. These results define the structure of RNA for full RIG-I activation and explain how RIG-I detects negative-strand RNA viruses that lack long double-stranded RNA but do contain blunt short double-stranded 5' triphosphate RNA in the panhandle region of their single-stranded genome."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2009.05.008"xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2009.05.008"xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Kawai T."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Kawai T."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Tuschl T."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Tuschl T."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Juranek S."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Juranek S."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Roth A."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Roth A."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Takeuchi O."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Fitzgerald K.A."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Fitzgerald K.A."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Hornung V."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Hornung V."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Latz E."xsd:string |
| http://purl.uniprot.org/citations/19576794 | http://purl.uniprot.org/core/author | "Latz E."xsd:string |