| http://purl.uniprot.org/citations/19597498 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19597498 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19597498 | http://www.w3.org/2000/01/rdf-schema#comment | "During positive selection, thymocytes transition through a stage during which T cell antigen receptor (TCR) signaling controls CD4-versus-CD8 lineage 'choice' and subsequent maturation. Here we describe a previously unknown T cell-specific protein, Themis, that serves a distinct function during this stage. In Themis(-/-) mice, thymocyte selection was impaired and the number of transitional CD4(+)CD8(int) thymocytes as well as CD4(+) or CD8(+) single-positive thymocytes was lower. Notably, although we detected no overt TCR-proximal signaling deficiencies, Themis(-/-) CD4(+)CD8(int) thymocytes showed developmental defects consistent with attenuated signaling that were reversible by TCR stimulation. Our results identify Themis as a critical component of the T cell developmental program and suggest that Themis functions to sustain and/or integrate signals required for proper lineage commitment and maturation."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1768"xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1768"xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Uehara S."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Uehara S."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Love P.E."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Love P.E."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Bosselut R."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Bosselut R."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Lesourne R."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Lesourne R."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Pinkhasov J."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Pinkhasov J."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Song K.-D."xsd:string |
| http://purl.uniprot.org/citations/19597498 | http://purl.uniprot.org/core/author | "Song K.-D."xsd:string |